The genetics of bipolar disorder
FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …
Major depressive disorder and bipolar disorder predispose youth to accelerated atherosclerosis and early cardiovascular disease: a scientific statement from the …
In the 2011 “Expert Panel on Integrated Guidelines for Cardiovascular Health and Risk
Reduction in Children and Adolescents,” several medical conditions among youth were …
Reduction in Children and Adolescents,” several medical conditions among youth were …
Genome-wide association study of more than 40,000 bipolar disorder cases provides new insights into the underlying biology
Bipolar disorder is a heritable mental illness with complex etiology. We performed a genome-
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
wide association study of 41,917 bipolar disorder cases and 371,549 controls of European …
Genome-wide association study identifies 30 loci associated with bipolar disorder
Bipolar disorder is a highly heritable psychiatric disorder. We performed a genome-wide
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
association study (GWAS) including 20,352 cases and 31,358 controls of European descent …
Biological insights from 108 schizophrenia-associated genetic loci
C Pantelis, GN Papadimitriou, S Papiol… - Nature, 2014 - nature.com
Schizophrenia is a highly heritable disorder. Genetic risk is conferred by a large number of
alleles, including common alleles of small effect that might be detected by genome-wide …
alleles, including common alleles of small effect that might be detected by genome-wide …
Identification of risk loci with shared effects on five major psychiatric disorders: a genome-wide analysis
Cross-Disorder Group of the Psychiatric Genomics … - The Lancet, 2013 - Elsevier
BACKGROUND: Findings from family and twin studies suggest that genetic contributions to
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …
psychiatric disorders do not in all cases map to present diagnostic categories. We aimed to …
Pleiotropy in complex traits: challenges and strategies
Genome-wide association studies have identified many variants that each affects multiple
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
traits, particularly across autoimmune diseases, cancers and neuropsychiatric disorders …
Genomic surveillance elucidates Ebola virus origin and transmission during the 2014 outbreak
SK Gire, A Goba, KG Andersen, RSG Sealfon, DJ Park… - science, 2014 - science.org
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra
Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra …
Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra …
Targeting voltage-gated calcium channels in neurological and psychiatric diseases
GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …
Genome-wide association study identifies five new schizophrenia loci
Nature genetics, 2011 - nature.com
We examined the role of common genetic variation in schizophrenia in a genome-wide
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …
association study of substantial size: a stage 1 discovery sample of 21,856 individuals of …