Innate TCRβ-chain engagement drives human T cells toward distinct memory-like effector phenotypes with immunotherapeutic potentials

P Vantourout, J Eum, M Conde Poole, TS Hayday… - Science …, 2023 - science.org
Clonotypic αβ T cell responses to cargoes presented by major histocompatibility complex
(MHC), MR1, or CD1 proteins underpin adaptive immunity. Those responses are mostly …

Toxins and superantigens of group A streptococci

BA Shannon, JK McCormick… - Microbiology …, 2019 - Am Soc Microbiol
Streptococcus pyogenes (ie, the group A Streptococcus) is a human-restricted and versatile
bacterial pathogen that produces an impressive arsenal of both surface-expressed and …

[HTML][HTML] The structure of superantigen complexed with TCR and MHC reveals novel insights into superantigenic T cell activation

M Saline, KEJ Rödström, G Fischer, VY Orekhov… - Nature …, 2010 - nature.com
Superantigens (SAgs) are bacterial toxins that interact with immunoreceptors, T cell receptor
(TCR) and major histocompatibility complex (MHC) class II, conventionally through the …

Clarifying the mechanism of superantigen toxicity

JD Fraser - PLoS biology, 2011 - journals.plos.org
Superantigens are bacterial proteins that generate a powerful immune response by binding
to Major Histocompatibility Complex class II molecules on antigen-presenting cells and T …

Display, engineering, and applications of antigen-specific T cell receptors

SA Richman, DM Kranz - Biomolecular engineering, 2007 - Elsevier
The use of T cell receptors (TCRs) as potential therapeutic agents provides an opportunity to
target a greatly expanded array of antigens, compared to those now targeted with …

HIV gp120 induces the release of proinflammatory, angiogenic, and lymphangiogenic factors from human lung mast cells

G Marone, FW Rossi, A Pecoraro, V Pucino… - Vaccines, 2020 - mdpi.com
Human lung mast cells (HLMCs) express the high-affinity receptor FcεRI for IgE and are
involved in chronic pulmonary diseases occurring at high frequency among HIV-infected …

ZDOCK predictions for the CAPRI challenge

R Chen, W Tong, J Mintseris, L Li… - … : Structure, Function, and …, 2003 - Wiley Online Library
The CAPRI Challenge is a blind test of protein–protein‐docking algorithms that predict the
complex structure from the crystal structures of the interacting proteins. We participated in …

Staphylococcal enterotoxin H induces Vα-specific expansion of T cells

K Petersson, H Pettersson, NJ Skartved… - The Journal of …, 2003 - journals.aai.org
Staphylococcal enterotoxin H (SEH) is a bacterial superantigen secreted by Staphylococcus
aureus. Superantigens are presented on the MHC class II and activate large amounts of T …

Interplay between superantigens and immunoreceptors

K Petersson, G Forsberg… - Scandinavian journal of …, 2004 - Wiley Online Library
Superantigens (SAGs) cause a massive T‐cell proliferation by simultaneously binding to
major histocompatibility complex (MHC) class II on antigen‐presenting cells and T‐cell …

CD1d‐independent activation of mouse and human iNKT cells by bacterial superantigens

JL Hayworth, DM Mazzuca, SM Vareki… - Immunology and cell …, 2012 - Wiley Online Library
Invariant NKT (iNKT) cells are infrequent but important immunomodulatory lymphocytes that
exhibit CD1d‐restricted reactivity with glycolipid Ags. iNKT cells express a unique T‐cell …