Recent large-scale studies of protein complexes in yeast have demonstrated that the wide
majority of proteins exist in the cell as parts of multicomponent assemblies, mostly novel and …

Bacterial superantigens (SAgs) are exotoxins produced mainly by Staphylococcus aureus
and Streptococcus pyogenes that can cause toxic shock syndrome (TSS). According to …

Superantigens are known to activate a large number of T cells. The SAg is presented by
MHC class II on the APC and its classical feature is that it recognizes the variable region of …

Staphylococcal enterotoxins A (SEA) and B (SEB) are classical models of superantigens
(SAg), which induce potent T-cell-stimulating activity by forming complexes with MHC class II …

The 3D‐Dock suite of programs has been used to make predictions for the seven targets in
rounds 1 and 2 of the CAPRI method evaluation exercise. Some correct contacts were …

Staphylococcus aureus and Streptococcus pyogenes secrete exotoxins that act as
superantigens, proteins that cause hyperimmune reactions by binding the variable domain …

Three mutants individually of both staphylococcal enterotoxins B and C were prepared by
site-specific mutagenesis of enterotoxin amino acids that contact host T lymphocyte immune …

Superantigens (SAgs) are microbial toxins defined by their ability to activate T lymphocytes
in a T cell receptor (TCR) β-chain variable domain (Vβ)-specific manner. Although existing …

The long‐range electrostatic forces of the targets in round 2 of the Critical Assessment of
PRediction of Interactions (CAPRI) experiment were examined and a simple guided docking …

The term superantigen (SAg) was coined in 1989 in the research group of Philippa Marrack
and John Kappler and describes a group of proteins with extremely high potency to …