Viral emerging diseases: challenges in developing vaccination strategies

M Trovato, R Sartorius, L D'Apice, R Manco… - Frontiers in …, 2020 - frontiersin.org
In the last decades, a number of infectious viruses have emerged from wildlife or re-
emerged, generating serious threats to the global health and to the economy worldwide …

The early landscape of coronavirus disease 2019 vaccine development in the UK and rest of the world

HR Sharpe, C Gilbride, E Allen… - …, 2020 - Wiley Online Library
Summary Since the first World Health Organization notification on 31 December 2019,
coronavirus disease 2019 (COVID‐19), the respiratory disease caused by the coronavirus …

Safety and immunogenicity of a 2-dose heterologous vaccination regimen with Ad26. ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a phase 1 …

Z Anywaine, H Whitworth, P Kaleebu… - The Journal of …, 2019 - academic.oup.com
Background Ebola vaccine development was accelerated in response to the 2014 Ebola
virus infection outbreak. This phase 1 study (VAC52150EBL1004) assessed safety …

Safety and immunogenicity of a 2-dose heterologous vaccine regimen with Ad26. ZEBOV and MVA-BN-Filo Ebola vaccines: 12-month data from a phase 1 …

G Mutua, O Anzala, K Luhn, C Robinson… - The Journal of …, 2019 - academic.oup.com
Abstract Background During the 2014 West African Ebola outbreak, Ebola vaccine
development was accelerated. The phase 1 VAC52150EBL1003 study was performed to …

Intradermal SynCon® Ebola GP DNA vaccine is temperature stable and safely demonstrates cellular and humoral immunogenicity advantages in healthy volunteers

P Tebas, KA Kraynyak, A Patel… - The Journal of …, 2019 - academic.oup.com
Background Nonlive vaccine approaches that are simple to deliver and stable at room
temperature or 2–8° C could be advantageous in controlling future Ebola virus (EBOV) …

Advances in designing and developing vaccines, drugs, and therapies to counter Ebola virus

K Dhama, K Karthik, R Khandia, S Chakraborty… - Frontiers in …, 2018 - frontiersin.org
Ebola virus (EBOV), a member of the family Filoviridae, is responsible for causing Ebola
virus disease (EVD)(formerly named Ebola hemorrhagic fever). This is a severe, often fatal …

Ebola vaccines, evidentiary charisma and the rise of global health emergency research

AH Kelly - Economy and Society, 2018 - Taylor & Francis
Abstract The 2013–2016 West African Ebola outbreak was both a catastrophic public health
disaster and a rare research opportunity. This paper analyses how the tensions between the …

Safety, immunogenicity and risk–benefit analysis of rVSV-ΔG-ZEBOV-GP (V920) Ebola vaccine in Phase I–III clinical trials across regions

BE Bache, MP Grobusch, ST Agnandji - Future microbiology, 2020 - Taylor & Francis
To evaluate the risk–benefits balance of the rVSV-ΔG-ZEBOV-GP vaccine. We performed a
systematic review to summarize data on safety, immunogenicity and efficacy. About 17,600 …

More than just gene therapy vectors: Lentiviral vector pseudotypes for serological investigation

K Toon, EM Bentley, G Mattiuzzo - Viruses, 2021 - mdpi.com
Serological assays detecting neutralising antibodies are important for determining the
immune responses following infection or vaccination and are also often considered a …

[PDF][PDF] Safety and immunogenicity of heterologous and homologous two dose regimens of Ad26-and MVA-vectored Ebola vaccines: a randomized, controlled phase 1 …

N Goldstein, V Bockstal, S Bart, K Luhn… - J Infect Dis, 2020 - scholar.archive.org
Safety and immunogenicity of two-dose regimens of Ad26. ZEBOV and MVA-BN-Filo
vaccines were evaluated in this phase 1 US study (healthy adults). Regimens were well …