The proteins of mRNA modification: writers, readers, and erasers

MN Flamand, M Tegowski… - Annual review of …, 2023 - annualreviews.org
Over the past decade, mRNA modifications have emerged as important regulators of gene
expression control in cells. Fueled in large part by the development of tools for detecting …

Polyacrylic acid nanoplatforms: Antimicrobial, tissue engineering, and cancer theranostic applications

H Arkaban, M Barani, MR Akbarizadeh… - Polymers, 2022 - mdpi.com
Polyacrylic acid (PAA) is a non-toxic, biocompatible, and biodegradable polymer that gained
lots of interest in recent years. PAA nano-derivatives can be obtained by chemical …

Anticancer drug-loading capacity of green synthesized porous magnetic iron nanocarrier and cytotoxic effects against human cancer cell line

MJ Ansari, SA Jasim, TZ Taban, DO Bokov… - Journal of Cluster …, 2023 - Springer
Porous hematite α-Fe2O3 nanoparticles (NPs) were synthesized using plant extract. The
physicochemical characteristics of resulting porous particles were determined using X-ray …

m6A methylation is required for dihydroartemisinin to alleviate liver fibrosis by inducing ferroptosis in hepatic stellate cells

M Shen, M Guo, Y Li, Y Wang, Y Qiu, J Shao… - Free Radical Biology …, 2022 - Elsevier
Activation of hepatic stellate cells (HSCs) is a central event in the development of liver
fibrosis, and the elimination of activated HSCs is considered to be an effective anti-fibrotic …

YTHDF1 upregulation mediates hypoxia-dependent breast cancer growth and metastasis through regulating PKM2 to affect glycolysis

X Yao, W Li, L Li, M Li, Y Zhao, D Fang, X Zeng… - Cell death & …, 2022 - nature.com
N6-methyladenosine modification is the most common RNA modification mechanism in
mammals. YTHDF1, a m6A reader, can recognize the m6A of mRNAs to facilitate the …

[HTML][HTML] YTHDF1 negatively regulates Treponema pallidum-induced inflammation in THP-1 macrophages by promoting SOCS3 translation in an m6A-dependent …

Z Li, M Teng, Y Jiang, L Zhang, X Luo, Y Liao… - Frontiers in …, 2022 - frontiersin.org
Background Previous studies have confirmed that the bacterium Treponema pallidum (TP)
or its proteins provide signals to macrophages that induce an inflammatory response; …

An optimized machine learning framework for predicting intradialytic hypotension using indexes of chronic kidney disease-mineral and bone disorders

X Yang, D Zhao, F Yu, AA Heidari, Y Bano… - Computers in Biology …, 2022 - Elsevier
Intradialytic hypotension (IDH) is the most common acute complication in hemodialysis (HD)
sessions and is associated with increased morbidity and mortality in HD patients. To prevent …

[HTML][HTML] Auricularia auricula polysaccharides attenuate obesity in mice through gut commensal Papillibacter cinnamivorans

X Zong, H Zhang, L Zhu, EC Deehan, J Fu… - Journal of Advanced …, 2023 - Elsevier
Introduction Auricularia auricula is a well-known traditional edible and medical fungus with
high nutritional and pharmacological values, as well as metabolic and immunoregulatory …

[HTML][HTML] m6A modification in inflammatory bowel disease provides new insights into clinical applications

J Zhang, B Song, Y Zeng, C Xu, L Gao, Y Guo… - Biomedicine & …, 2023 - Elsevier
Inflammatory bowel disease (IBD) results from a complex interplay between genetic
predisposition, environmental factors, and gut microbes. The role of N6-methyladenosine …

METTL3 regulates LPS-induced inflammatory response via the NOD1 signaling pathway

Y Cai, R Yu, Y Kong, Z Feng, Q Xu - Cellular Signalling, 2022 - Elsevier
Abstract N 6-methyladenosine (m 6 A) is a prevalent mRNA modification that plays a crucial
function in multiple biological processes. Methyltransferase-like 3 (METTL3), an m 6 A …