Angiotensin II signal transduction: an update on mechanisms of physiology and pathophysiology
The renin-angiotensin-aldosterone system plays crucial roles in cardiovascular physiology
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
and pathophysiology. However, many of the signaling mechanisms have been unclear. The …
Cerebral vascular disease and neurovascular injury in ischemic stroke
The consequences of cerebrovascular disease are among the leading health issues
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …
worldwide. Large and small cerebral vessel disease can trigger stroke and contribute to the …
Hypertension in HIV-infected adults: novel pathophysiologic mechanisms
Fahme et al Mechanisms of Hypertension in HIV 45 have been shown to be associated with
hypertension in the context of HIV infection. 23, 34 In a nested, case–control study of HIV …
hypertension in the context of HIV infection. 23, 34 In a nested, case–control study of HIV …
AT1 receptor signaling pathways in the cardiovascular system
The importance of the renin angiotensin aldosterone system in cardiovascular physiology
and pathophysiology has been well described whereas the detailed molecular mechanisms …
and pathophysiology has been well described whereas the detailed molecular mechanisms …
Oxidative stress, reductive stress and antioxidants in vascular pathogenesis and aging
M Mladenov, L Lubomirov, O Grisk, D Avtanski… - Antioxidants, 2023 - mdpi.com
This review is focused on the mechanisms that regulate health, disease and aging redox
status, the signal pathways that counteract oxidative and reductive stress, the role of food …
status, the signal pathways that counteract oxidative and reductive stress, the role of food …
Role of the peroxisome proliferator activated receptors in hypertension
S Fang, MC Livergood, P Nakagawa, J Wu… - Circulation …, 2021 - Am Heart Assoc
Nuclear receptors represent a large family of ligand-activated transcription factors which
sense the physiological environment and make long-term adaptations by mediating …
sense the physiological environment and make long-term adaptations by mediating …
[HTML][HTML] Cullin-3 mutation causes arterial stiffness and hypertension through a vascular smooth muscle mechanism
Abstract Cullin-3 (CUL3) mutations (CUL3Δ9) were previously identified in hypertensive
patients with pseudohypoaldosteronism type-II (PHAII), but the mechanism causing …
patients with pseudohypoaldosteronism type-II (PHAII), but the mechanism causing …
RhoBTB1 protects against hypertension and arterial stiffness by restraining phosphodiesterase 5 activity
Mice selectively expressing a PPARγ dominant-negative mutation in vascular smooth
muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic …
muscle exhibit RhoBTB1 deficiency and hypertension. Our rationale was to use genetic …
Biomechanical forces and oxidative stress: implications for pulmonary vascular disease
EA Zemskov, Q Lu, W Ornatowski… - Antioxidants & redox …, 2019 - liebertpub.com
Significance: Oxidative stress in the cell is characterized by excessive generation of reactive
oxygen species (ROS). Superoxide (O2−) and hydrogen peroxide (H2O2) are the main ROS …
oxygen species (ROS). Superoxide (O2−) and hydrogen peroxide (H2O2) are the main ROS …
Impact of the renin–angiotensin system on the endothelium in vascular dementia: Unresolved issues and future perspectives
The effects of the renin–angiotensin system (RAS) surpass the renal and cardiovascular
systems to encompass other body tissues and organs, including the brain. Angiotensin II …
systems to encompass other body tissues and organs, including the brain. Angiotensin II …