Data-driven analysis and characterization of molecular phenotypes comprises an efficient
way to decipher complex disease mechanisms. Using emerging next generation …

Recently, immunotherapy has gained increasing popularity in oncology. Several
immunotherapies obtained remarkable clinical effects, but the efficacy varied, and only …

The development of sequencing methods has resulted in the investigation of many
unexplored research areas. Among the different sequencing methods, single-cell …

Placental development is a tightly controlled event, in which cell expansion from the
trophectoderm occurs in a spatiotemporal manner. Proper trophoblast differentiation is …

The senescence of fruit is a complex physiological process, with various cell types within the
pericarp, making it highly challenging to elucidate their individual roles in fruit senescence …

The interaction between the peripheral immune system and the brain is increasingly being
recognized as an important layer of neuroimmune regulation and plays vital roles in brain …

Immunotherapy plays a key role in cancer treatment, however, responses are limited to a
small number of patients. The biological basis for the success of immunotherapy is the …

The field of immuno-oncology is now at the forefront of cancer care and is rapidly evolving.
The immune checkpoint blockade has been demonstrated to restore antitumor responses in …

Background Previous studies have traditionally attributed the initiation of cancer cells to
genetic mutations, considering them as the fundamental drivers of carcinogenesis. However …

Developmental patterning is essential for regulating cellular events such as axial patterning,
segmentation, tissue formation, and organ size determination during embryogenesis …