Platelets are generated and released into the bloodstream from their precursor cells,
megakaryocytes that reside in the bone marrow. Though platelets have no nucleus or DNA …

Methods that measure the transcriptomic state of thousands of individual cells have
transformed our understanding of cellular heterogeneity in eukaryotic cells since their …

The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …

Background Single-cell RNA sequencing (scRNA-seq) provides high-resolution
transcriptome data to understand the heterogeneity of cell populations at the single-cell …

Recent development of human three-dimensional organoid cultures has opened new doors
and opportunities ranging from modelling human development in vitro to personalised …

Mammalian apurinic/apyrimidinic endonuclease 1 (APE1, APEX1) is a multifunctional
enzyme that maintains cellular homeostasis. It is involved in the base excision repair (BER) …

Mesenchymal stem/stromal cells (MSCs) represent a heterogeneous cell population
distributed throughout various tissues, demonstrating remarkable adaptability to …

Carbapenem-resistant Escherichia coli (E. coli) strains are widely distributed and spreading
rapidly, creating significant challenges for clinical therapeutics. NDM-5, a novel mutant of …

The versatility of somatosensation arises from heterogeneous dorsal root ganglion (DRG)
neurons. However, soma transcriptomes of individual human DRG (hDRG) neurons–critical …