Traumatic brain injury (TBI) can result in long-lasting changes in hippocampal function. The
changes induced by TBI on the hippocampus contribute to cognitive deficits. The adult …

Highlights•Microfluidics can create and control chemical gradients to induce tissue
patterning.•Microfluidics can control material transport and physical environment.• …

PROteolysis TArgeting Chimera (PROTAC) is an emerging technology in chemical biology
and drug discovery. This technique facilitates the complete removal of the target proteins …

Mammalian apurinic/apyrimidinic endonuclease 1 (APE1, APEX1) is a multifunctional
enzyme that maintains cellular homeostasis. It is involved in the base excision repair (BER) …

The liver is an immune organ that plays a vital role in the detection, capture, and clearance
of pathogens and foreign antigens that invade the human body. During acute and chronic …

The specific mechanism of clear cell renal cell carcinoma (ccRCC) progression, a
pathological type that accounts for the highest proportion of RCC, remains unclear. In this …

Pluripotent stem cells are endless sources for in vitro engineering human tissues for
regenerative medicine. Extensive studies have demonstrated that transcription factors are …

The treatment landscape for multiple myeloma (MM) has experienced substantial progress
over the last decade. Despite the efficacy of new substances, patient responses tend to still …

With the development of sequencing technology and the dramatic drop in sequencing cost,
the functions of noncoding genes are being characterized in a wide variety of fields (eg …

Background Alternative splicing (AS) is an omnipresent regulatory mechanism of gene
expression that enables the generation of diverse splice isoforms from a single gene …