Due to the high dimensionality and sparsity of the gene expression matrix in single-cell RNA-
sequencing (scRNA-seq) data, coupled with significant noise generated by shallow …

Historically believed to be a homogeneous cell type that is often overlooked, fibroblasts are
more and more understood to be heterogeneous in nature. Though the mechanisms behind …

Within the developing embryo is a microcosm of cell type diversity. Single cell RNA-
sequencing (scRNA-seq) is used to reveal cell types, typically by grouping cells according to …

Tumor-associated macrophages (TAM) subtypes have been shown to impact cancer
prognosis and resistance to immunotherapy. However, there is still a lack of systematic …

Background: In patients with hepatocellular carcinoma (HCC), the tumor microenvironment
(TME) is resistant to immunotherapy because of its specificity. It is meaningful to explore the …

Single-cell biology has revolutionized the way we understand biological processes. In this
paper, we provide a more tailored approach to clustering and analyzing spatial single-cell …

Dear Editor, The single cell RNA sequencing (scRNA-seq) technology provides new insights
into understanding of single-cell transcriptomic atlas and intercellular communication. 1 …

Tea plants are an economically important crop and conducting research on tea breeding
contributes to enhancing the yield and quality of tea leaves as well as breeding traits that …

Transcriptome analysis of individual cells by single-cell RNA-seq (scRNA-seq) has become
routine for eukaryotic tissues, even being applied to whole multicellular organisms. In …

Traditionally, diagnostic pathology uses histology representing structural alterations in a
disease's cells and tissues. In many cases, however, it is supplemented by other …