Ocular neurodegenerative diseases: interconnection between retina and cortical areas

N Marchesi, F Fahmideh, F Boschi, A Pascale… - Cells, 2021 - mdpi.com
The possible interconnection between the eye and central nervous system (CNS) has been
a topic of discussion for several years just based on fact that the eye is properly considered …

Novel imaging biomarkers in diabetic retinopathy and diabetic macular edema

A Markan, A Agarwal, A Arora… - Therapeutic …, 2020 - journals.sagepub.com
Diabetic retinopathy is one of the major microvascular complications of diabetes mellitus.
The most common causes of vision loss in diabetic retinopathy are diabetic macular edema …

Exploiting epistemic uncertainty of anatomy segmentation for anomaly detection in retinal OCT

P Seeböck, JI Orlando, T Schlegl… - IEEE transactions on …, 2019 - ieeexplore.ieee.org
Diagnosis and treatment guidance are aided by detecting relevant biomarkers in medical
images. Although supervised deep learning can perform accurate segmentation of …

Cellular stress signaling and the unfolded protein response in retinal degeneration: mechanisms and therapeutic implications

T McLaughlin, A Medina, J Perkins, M Yera… - Molecular …, 2022 - Springer
Background The retina, as part of the central nervous system (CNS) with limited capacity for
self-reparation and regeneration in mammals, is under cumulative environmental stress due …

Retinal neurodegeneration in diabetes: an emerging concept in diabetic retinopathy

MM Sachdeva - Current diabetes reports, 2021 - Springer
Abstract Purpose of Review Diabetic retinopathy (DR), the leading cause of blindness in
working-aged adults, remains clinically defined and staged by its vascular manifestations …

Optical coherence tomography (angiography) biomarkers in the assessment and monitoring of diabetic macular edema

CI Suciu, VI Suciu, SD Nicoara - Journal of Diabetes Research, 2020 - Wiley Online Library
Retinopathy is one of the most severe diabetes‐related complications, and macular edema
is the major cause of central vision loss in patients with diabetes mellitus. Significant …

The endoplasmic reticulum: homeostasis and crosstalk in retinal health and disease

SX Zhang, JJ Wang, CR Starr, EJ Lee, S Park… - Progress in retinal and …, 2023 - Elsevier
The endoplasmic reticulum (ER) is the largest intracellular organelle carrying out a broad
range of important cellular functions including protein biosynthesis, folding, and trafficking …

Optical coherence tomography in the management of diabetic macular oedema

SKH Szeto, TYY Lai, S Vujosevic, JK Sun… - Progress in Retinal and …, 2023 - Elsevier
Diabetic macular oedema (DMO) is the major cause of visual impairment in people with
diabetes. Optical coherence tomography (OCT) is now the most widely used modality to …

It is time for a moonshot to find “Cures” for diabetic retinal disease

SR Levine, P Sapieha, S Dutta, JK Sun… - Progress in Retinal and …, 2022 - Elsevier
Diabetic retinal disease (DRD), the most common complication of diabetes and a leading
cause of blindness in working age individuals, is now understood to be a form of sensory …

Advances in cell therapies using stem cells/progenitors as a novel approach for neurovascular repair of the diabetic retina

J Lechner, RJ Medina, N Lois, AW Stitt - Stem Cell Research & Therapy, 2022 - Springer
Background Diabetic retinopathy, a major complication of diabetes mellitus, is a leading
cause of sigh-loss in working age adults. Progressive loss of integrity of the retinal …