Tools and techniques for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)/COVID-19 detection

SH Safiabadi Tali, JJ LeBlanc, Z Sadiq… - Clinical microbiology …, 2021 - Am Soc Microbiol
SUMMARY The coronavirus disease 2019 (COVID-19) pandemic, caused by severe acute
respiratory disease coronavirus 2 (SARS-CoV-2), has led to millions of confirmed cases and …

Antibody tests for identification of current and past infection with SARS‐CoV‐2

T Fox, J Geppert, J Dinnes, K Scandrett… - Cochrane database …, 2022 - cochranelibrary.com
Background The diagnostic challenges associated with the COVID‐19 pandemic resulted in
rapid development of diagnostic test methods for detecting SARS‐CoV‐2 infection. Serology …

Engineering luminescent biosensors for point-of-care SARS-CoV-2 antibody detection

SK Elledge, XX Zhou, JR Byrnes, AJ Martinko… - Nature …, 2021 - nature.com
Current serology tests for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
antibodies mainly take the form of enzyme-linked immunosorbent assays, chemiluminescent …

Bi-paratopic and multivalent VH domains block ACE2 binding and neutralize SARS-CoV-2

CJ Bracken, SA Lim, P Solomon, NJ Rettko… - Nature chemical …, 2021 - nature.com
Neutralizing agents against SARS-CoV-2 are urgently needed for the treatment and
prophylaxis of COVID-19. Here, we present a strategy to rapidly identify and assemble …

Challenges and opportunities for antiviral monoclonal antibodies as COVID-19 therapy

C Cruz-Teran, K Tiruthani, M McSweeney, A Ma… - Advanced drug delivery …, 2021 - Elsevier
To address the COVID-19 pandemic, there has been an unprecedented global effort to
advance potent neutralizing mAbs against SARS-CoV-2 as therapeutics. However, historical …

Diagnostics and analysis of SARS-CoV-2: current status, recent advances, challenges and perspectives

T Dong, M Wang, J Liu, P Ma, S Pang, W Liu… - Chemical Science, 2023 - pubs.rsc.org
The disastrous spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2)
has induced severe public healthcare issues and weakened the global economy …

Computational design of potent D-peptide inhibitors of SARS-CoV-2

PA Valiente, H Wen, S Nim, JA Lee… - Journal of medicinal …, 2021 - ACS Publications
Blocking the association between the severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) spike protein receptor-binding domain (RBD) and the human angiotensin …

A third dose of the unmodified COVID-19 mRNA vaccine CVnCoV enhances quality and quantity of immune responses

K Lenart, F Hellgren, S Ols, X Yan, A Cagigi… - … Therapy-Methods & …, 2022 - cell.com
A third vaccine dose is often required to achieve potent, long-lasting immune responses. We
investigated the effect of three 8-μg doses of CVnCoV, CureVac's severe acute respiratory …

SARS-CoV-2 serum neutralization assay: a traditional tool for a brand-new virus

G Matusali, F Colavita, D Lapa, S Meschi, L Bordi… - Viruses, 2021 - mdpi.com
SARS-CoV-2 serum neutralization assay represents the gold standard for assessing
antibody-mediated protection in naturally infected and vaccinated individuals. In the present …

Advances in neutralization assays for SARS‐CoV‐2

Y Lu, J Wang, Q Li, H Hu, J Lu… - Scandinavian Journal of …, 2021 - Wiley Online Library
Abstract The coronavirus disease 2019 (COVID‐19) pandemic has triggered a global health
emergency and brought disaster to humans. Tremendous efforts have been made to control …