Epidemiology of venous thromboembolism

JA Heit - Nature Reviews Cardiology, 2015 - nature.com
Thrombosis can affect any venous circulation. Venous thromboembolism (VTE) includes
deep-vein thrombosis of the leg or pelvis, and its complication, pulmonary embolism. VTE is …

Environmental and genetic risk factors associated with venous thromboembolism

M Crous-Bou, LB Harrington… - Seminars in thrombosis …, 2016 - thieme-connect.com
Venous thromboembolism (VTE) includes deep vein thrombosis and pulmonary embolism,
and a combination of environmental and genetic risk factors contributes to VTE risk. Within …

[HTML][HTML] Associations between blood type and COVID-19 infection, intubation, and death

M Zietz, J Zucker, NP Tatonetti - Nature communications, 2020 - nature.com
The rapid global spread of the novel coronavirus SARS-CoV-2 has strained healthcare and
testing resources, making the identification and prioritization of individuals most at-risk a …

Deep learning sequence-based ab initio prediction of variant effects on expression and disease risk

J Zhou, CL Theesfeld, K Yao, KM Chen, AK Wong… - Nature …, 2018 - nature.com
Key challenges for human genetics, precision medicine and evolutionary biology include
deciphering the regulatory code of gene expression and understanding the transcriptional …

Genomic and transcriptomic association studies identify 16 novel susceptibility loci for venous thromboembolism

S Lindström, LU Wang, EN Smith… - Blood, The Journal …, 2019 - ashpublications.org
Venous thromboembolism (VTE) is a significant contributor to morbidity and mortality. To
advance our understanding of the biology contributing to VTE, we conducted a genome …

[PDF][PDF] Meta-analysis of 65,734 individuals identifies TSPAN15 and SLC44A2 as two susceptibility loci for venous thromboembolism

M Germain, DI Chasman, H De Haan, W Tang… - The American Journal of …, 2015 - cell.com
Venous thromboembolism (VTE), the third leading cause of cardiovascular mortality, is a
complex thrombotic disorder with environmental and genetic determinants. Although several …

Genome-wide association analysis of venous thromboembolism identifies new risk loci and genetic overlap with arterial vascular disease

D Klarin, E Busenkell, R Judy, J Lynch, M Levin… - Nature …, 2019 - nature.com
Venous thromboembolism is a significant cause of mortality, yet its genetic determinants are
incompletely defined. We performed a discovery genome-wide association study in the …

[HTML][HTML] Phenome-wide association studies across large population cohorts support drug target validation

D Diogo, C Tian, CS Franklin… - Nature …, 2018 - nature.com
Phenome-wide association studies (PheWAS) have been proposed as a possible aid in
drug development through elucidating mechanisms of action, identifying alternative …

Genetic variants in mRNA untranslated regions

M Steri, ML Idda, MB Whalen… - Wiley Interdisciplinary …, 2018 - Wiley Online Library
Genome Wide Association Studies (GWAS) have mapped thousands of genetic variants
associated with complex disease risk and regulating quantitative traits, thus exploiting an …

Cross-ancestry investigation of venous thromboembolism genomic predictors

F Thibord, D Klarin, JA Brody, MH Chen, MG Levin… - Circulation, 2022 - Am Heart Assoc
Background: Venous thromboembolism (VTE) is a life-threatening vascular event with
environmental and genetic determinants. Recent VTE genome-wide association studies …