Parkinson's disease (PD) is one of the most prevalent neurodegenerative diseases. The
typical symptomatology of PD includes motor symptoms; however, a range of nonmotor …

The gut and brain are increasingly linked in human disease, with neuropsychiatric
conditions classically attributed to the brain showing an involvement of the intestine and …

Gut-brain axis and inflammation are two hot topics in Parkinson's disease (PD). In this
setting, the leucine-rich repeat kinase 2 (LRRK2) gene, which encodes the eponym protein …

The synovium is an important component of any synovial joint and is the major target tissue
of inflammatory arthritis. However, the multi-omics landscape of synovium required for …

Leucine-rich repeat kinase 2 (LRRK2) is a serine–threonine protein kinase belonging to the
ROCO protein family. Within the kinase domain of LRRK2, a point mutation known as …

Parkinson's disease (PD) is characterised neuropathologically by the degeneration of
dopaminergic neurons in the ventral midbrain, the accumulation of α-synuclein (α-syn) …

Ulcerative colitis (UC) is an inflammatory bowel disease that is often resistant to current
treatment options, leading to a need for alternative therapies. Herbal products have shown …

Abstract LRRK2 G2019S is the most prevalent variant associated with Parkinson's disease
(PD), found in 1-3% of sporadic and 4-8% of familial PD cases. Intriguingly, emerging …

The multiple hypothesis holds that the pathogenesis of Parkinson's disease (PD) requires
many factors such as heredity, environment and ageing. Mutations in Leucine-rich repeat …

Parkinson's disease (PD) is characterized by a decades-long prodrome, consisting of a
collection of non-motor symptoms that emerges prior to the motor manifestation of the …