Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

Alzheimer's disease (AD) is a progressive neurodegenerative disorder that is characterized
by cognitive decline and the presence of two core pathologies, amyloid β plaques and …

One of the biggest challenges in the development of therapeutics for central nervous system
(CNS) disorders is achieving sufficient blood–brain barrier (BBB) penetration. Research in …

The past two decades of research into the pathogenesis of Alzheimer disease (AD) have
been driven largely by the amyloid hypothesis; the neuroinflammation that is associated with …

Brain capillary endothelial cells form the blood-brain barrier (BBB), which is covered with
basement membranes and is also surrounded by pericytes and astrocyte end-feet in the …

This review proposes that lipopolysaccharide (LPS, found in the wall of all Gram-negative
bacteria) could play a role in causing sporadic Alzheimer's disease (AD). This is based in …

There is an increasing prevalence of Vascular Cognitive Impairment (VCI) worldwide, and
several studies have suggested that Chronic Cerebral Hypoperfusion (CCH) plays a critical …

The neurovascular unit (NVU) comprises brain endothelial cells, pericytes or vascular
smooth muscle cells, glia and neurons. The NVU controls blood–brain barrier (BBB) …

The blood-brain barrier (BBB), constituted by an extensive network of endothelial cells (ECs)
together with neurons and glial cells, including microglia, forms the neurovascular unit …

Human apolipoprotein E has three isoforms: APOE2, APOE3 and APOE4. APOE4 is a major
genetic risk factor for Alzheimer's disease, and is associated with Down's syndrome …