Differences in genetic risk score profiles for drug use disorder, major depression, and ADHD as a function of sex, age at onset, recurrence, mode of ascertainment, and …
Background Do genetic risk profiles for drug use disorder (DUD), major depression (MD),
and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex …
and attention-deficit hyperactivity disorder (ADHD) differ substantially as a function of sex …
[HTML][HTML] Genome-and transcriptome-wide splicing associations with alcohol use disorder
Genetic mechanisms of alternative mRNA splicing have been shown in the brain for a
variety of neuropsychiatric traits, but not substance use disorders. Our study utilized RNA …
variety of neuropsychiatric traits, but not substance use disorders. Our study utilized RNA …
[HTML][HTML] Genome-wide association studies and cross-population meta-analyses investigating short and long sleep duration
I Austin-Zimmerman, DF Levey… - Nature …, 2023 - nature.com
Sleep duration has been linked to a wide range of negative health outcomes and to reduced
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …
life expectancy. We present genome-wide association studies of short (≤ 5 h) and long (≥ …
[HTML][HTML] Role of neuronal nicotinic acetylcholine receptors in cannabinoid dependence
Cannabis is among the most widely consumed psychoactive drugs around the world and
cannabis use disorder (CUD) has no current approved pharmacological treatment. Nicotine …
cannabis use disorder (CUD) has no current approved pharmacological treatment. Nicotine …
The Collaborative Study on the Genetics of Alcoholism: Overview
A Agrawal, SJ Brislin, KK Bucholz… - Genes, Brain and …, 2023 - Wiley Online Library
Alcohol use disorders (AUD) are commonly occurring, heritable and polygenic disorders
with etiological origins in the brain and the environment. To outline the causes and …
with etiological origins in the brain and the environment. To outline the causes and …
Leveraging related health phenotypes for polygenic prediction of impulsive choice, impulsive action, and impulsive personality traits in 1534 European ancestry …
Impulsivity refers to a number of conceptually related phenotypes reflecting self‐regulatory
capacity that are considered promising endophenotypes for mental and physical health …
capacity that are considered promising endophenotypes for mental and physical health …
Comorbidity between mood and substance-related disorders: A systematic review and meta-analysis
Background and Objectives: Evidence indicates that mood disorders often co-occur with
substance-related disorders. However, pooling comorbidity estimates can be challenging …
substance-related disorders. However, pooling comorbidity estimates can be challenging …
Novel biological insights into the common heritable liability to substance involvement: a multivariate genome-wide association study
Background Consumption of nicotine, alcohol, and cannabis commonly co-occurs, which is
thought to partly stem from a common heritable liability to substance involvement. Methods …
thought to partly stem from a common heritable liability to substance involvement. Methods …
The collaborative study on the genetics of alcoholism: Sample and clinical data
The collaborative study on the genetics of alcoholism (COGA) is a multi‐site,
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …
multidisciplinary project with the goal of identifying how genes are involved in alcohol use …
Nongenetic factors associated with psychotic experiences among UK Biobank participants: exposome-wide analysis and Mendelian randomization analysis
Importance Although hypothesis-driven research has identified several factors associated
with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity …
with psychosis, this one-exposure-to-one-outcome approach fails to embrace the multiplicity …