[HTML][HTML] Chronic adolescent exposure to cannabis in mice leads to sex-biased changes in gene expression networks across brain regions
During adolescence, frequent and heavy cannabis use can lead to serious adverse health
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
effects and cannabis use disorder (CUD). Rodent models of adolescent exposure to the …
[HTML][HTML] Testing the causal relationships of physical activity and sedentary behaviour with mental health and substance use disorders: a Mendelian randomisation …
Observational studies suggest that physical activity can reduce the risk of mental health and
substance use disorders. However, it is unclear whether this relationship is causal or …
substance use disorders. However, it is unclear whether this relationship is causal or …
Depression pathophysiology, risk prediction of recurrence and comorbid psychiatric disorders using genome-wide analyses
Depression is a common psychiatric disorder and a leading cause of disability worldwide.
Here we conducted a genome-wide association study meta-analysis of six datasets …
Here we conducted a genome-wide association study meta-analysis of six datasets …
Integration of evidence across human and model organism studies: A meeting report
Abstract The National Institute on Drug Abuse and Joint Institute for Biological Sciences at
the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of …
the Oak Ridge National Laboratory hosted a meeting attended by a diverse group of …
[HTML][HTML] Disentangling heterogeneity in substance use disorder: Insights from genome-wide polygenic scores
L Vilar-Ribó, J Cabana-Domínguez, S Alemany… - Translational …, 2024 - nature.com
Substance use disorder (SUD) is a global health problem with a significant impact on
individuals and society. The presentation of SUD is diverse, involving various substances …
individuals and society. The presentation of SUD is diverse, involving various substances …
[HTML][HTML] Parsing genetically influenced risk pathways: genetic loci impact problematic alcohol use via externalizing and specific risk
Genome-wide association studies (GWAS) identify genetic variants associated with a trait,
regardless of how those variants are associated with the outcome. Characterizing whether …
regardless of how those variants are associated with the outcome. Characterizing whether …
Genetics in psychiatry: Methods, clinical applications and future perspectives
C Fabbri - Psychiatry and Clinical Neurosciences Reports, 2022 - Wiley Online Library
Psychiatric disorders and related traits have a demonstrated genetic component, with
heritability estimated by twin studies generally between 80% and 40%. Their pathogenesis …
heritability estimated by twin studies generally between 80% and 40%. Their pathogenesis …
First-episode psychosis patients who deteriorated in the premorbid period do not have higher polygenic risk scores than others: a cluster analysis of EU-GEI data
L Ferraro, D Quattrone, D La Barbera… - Schizophrenia …, 2023 - academic.oup.com
Cluster studies identified a subgroup of patients with psychosis whose premorbid
adjustment deteriorates before the onset, which may reflect variation in genetic influence …
adjustment deteriorates before the onset, which may reflect variation in genetic influence …
[HTML][HTML] Identifying potential risk genes and pathways for neuropsychiatric and substance use disorders using intermediate molecular mediator information
H Gedik, TH Nguyen, RE Peterson… - Frontiers in …, 2023 - frontiersin.org
Neuropsychiatric and substance use disorders (NPSUDs) have a complex etiology that
includes environmental and polygenic risk factors with significant cross-trait genetic …
includes environmental and polygenic risk factors with significant cross-trait genetic …
Independent contribution of polygenic risk for schizophrenia and cannabis use in predicting psychotic-like experiences in young adulthood: testing gene× environment …
Background It has not yet been determined if the commonly reported cannabis–psychosis
association is limited to individuals with pre-existing genetic risk for psychotic disorders …
association is limited to individuals with pre-existing genetic risk for psychotic disorders …