Intranasal COVID-19 vaccines: From bench to bed

A Alu, L Chen, H Lei, Y Wei, X Tian, X Wei - EBioMedicine, 2022 - thelancet.com
Currently licensed COVID-19 vaccines are all designed for intramuscular (IM) immunization.
However, vaccination today failed to prevent the virus infection through the upper respiratory …

Recent advances in the development of toll-like receptor agonist-based vaccine adjuvants for infectious diseases

JX Yang, JC Tseng, GY Yu, Y Luo, CYF Huang… - Pharmaceutics, 2022 - mdpi.com
Vaccines are powerful tools for controlling microbial infections and preventing epidemic
diseases. Efficient inactive, subunit, or viral-like particle vaccines usually rely on a safe and …

Bridging nanoplatform and vaccine delivery, a landscape of strategy to enhance nasal immunity

Z Teng, LY Meng, JK Yang, Z He, XG Chen… - Journal of Controlled …, 2022 - Elsevier
Vaccination is an urgently needed and effective option to address epidemic, cancers,
allergies, and other diseases. Nasal administration of vaccines offers many benefits over …

Development of variant‐proof severe acute respiratory syndrome coronavirus 2, pan‐sarbecovirus, and pan‐β‐coronavirus vaccines

J Zhou, Z Liu, G Zhang, W Xu, L Xing… - Journal of Medical …, 2023 - Wiley Online Library
The newly emerged severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)
variants with high transmission rates and striking immune evasion have posed a serious …

Different methods and formulations of drugs and vaccines for nasal administration

J Tai, M Han, D Lee, IH Park, SH Lee, TH Kim - Pharmaceutics, 2022 - mdpi.com
Nasal drug delivery is advantageous when compared with other routes of drug delivery as it
avoids the hepatic first-pass effect, blood–brain barrier penetration, and compliance issues …

Nasal delivery as a strategy for the prevention and treatment of COVID-19

F Sonvico, G Colombo, E Quarta… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction The upper respiratory tract is a major route of infection for COVID-19 and other
respiratory diseases. Thus, it appears logical to exploit the nose as administration site to …

[HTML][HTML] The unfulfilled potential of mucosal immunization

JR Baker Jr, M Farazuddin, PT Wong… - Journal of Allergy and …, 2022 - Elsevier
Recent events involving the global coronavirus pandemic have focused attention on
vaccination strategies. Although tremendous advances have been made in subcutaneous …

[HTML][HTML] Clinical perspective on topical vaccination strategies

P Popova, SP Chen, S Liao, M Sadarangani… - Advanced Drug Delivery …, 2024 - Elsevier
Vaccination is one of the most successful measures in modern medicine to combat
diseases, especially infectious diseases, and saves millions of lives every year. Vaccine …

Feasibility of intranasal delivery of thin-film freeze-dried, mucoadhesive vaccine powders

YS Yu, K AboulFotouh, H Xu, G Williams… - International Journal of …, 2023 - Elsevier
Intranasal vaccination by directly applying a vaccine dry powder is appealing. However, a
method that can be used to transform a vaccine from a liquid to a dry powder and a device …

Intranasal administration of a single dose of MVA-based vaccine candidates against COVID-19 induced local and systemic immune responses and protects mice from …

P Pérez, D Astorgano, G Albericio, S Flores… - Frontiers in …, 2022 - frontiersin.org
Current coronavirus disease-19 (COVID-19) vaccines are administered by the intramuscular
route, but this vaccine administration failed to prevent severe acute respiratory syndrome …