SARS-CoV-2 reservoir in post-acute sequelae of COVID-19 (PASC)

AD Proal, MB VanElzakker, S Aleman, K Bach… - Nature …, 2023 - nature.com
Millions of people are suffering from Long COVID or post-acute sequelae of COVID-19
(PASC). Several biological factors have emerged as potential drivers of PASC pathology …

Detrimental effects of COVID-19 in the brain and therapeutic options for long COVID: the role of Epstein–Barr virus and the gut–brain axis

K Hashimoto - Molecular Psychiatry, 2023 - nature.com
Abstract The coronavirus disease 2019 (COVID-19) pandemic caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has resulted in a serious public …

Long COVID manifests with T cell dysregulation, inflammation and an uncoordinated adaptive immune response to SARS-CoV-2

K Yin, MJ Peluso, X Luo, R Thomas, MG Shin… - Nature …, 2024 - nature.com
Long COVID (LC) occurs after at least 10% of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections, yet its etiology remains poorly understood. We used …

Therapeutic trials for long COVID-19: A call to action from the interventions taskforce of the RECOVER initiative

H Bonilla, MJ Peluso, K Rodgers, JA Aberg… - Frontiers in …, 2023 - frontiersin.org
Although most individuals recover from acute SARS-CoV-2 infection, a significant number
continue to suffer from Post-Acute Sequelae of SARS-CoV-2 (PASC), including the …

Immune mechanisms underlying COVID-19 pathology and post-acute sequelae of SARS-CoV-2 infection (PASC)

S Mohandas, P Jagannathan, TJ Henrich, ZA Sherif… - Elife, 2023 - elifesciences.org
With a global tally of more than 500 million cases of severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infections to date, there are growing concerns about the post …

Long COVID: Clinical characteristics, proposed pathogenesis and potential therapeutic targets

G Kenny, L Townsend, S Savinelli… - Frontiers in Molecular …, 2023 - frontiersin.org
The emergence of persistent ill-health in the aftermath of SARS-CoV-2 infection has
presented significant challenges to patients, healthcare workers and researchers. Termed …

Long COVID and rheumatology: Clinical, diagnostic, and therapeutic implications

C Calabrese, E Kirchner, LH Calabrese - Best Practice & Research Clinical …, 2022 - Elsevier
As of this writing, it is estimated that there have been nearly 600 million cases of coronavirus
disease 2019 (COVID-19) around the world with over six million deaths. While shocking …

[HTML][HTML] Autoantigen profiling reveals a shared post-COVID signature in fully recovered and long COVID patients

A Bodansky, CY Wang, A Saxena, A Mitchell, AF Kung… - JCI insight, 2023 - ncbi.nlm.nih.gov
Some individuals do not return to baseline health following SARS-CoV-2 infection, leading
to a condition known as long COVID. The underlying pathophysiology of long COVID …

Tissue injury and leukocyte changes in post-acute sequelae of SARS-CoV-2: review of 2833 post-acute patient outcomes per immune dysregulation and microbial …

MS Islam, Z Wang, M Abdel-Mohsen… - Journal of Leukocyte …, 2023 - academic.oup.com
A significant number of persons with coronavirus disease 2019 (COVID-19) experience
persistent, recurrent, or new symptoms several months after the acute stage of severe acute …

[HTML][HTML] Biological mechanisms underpinning the development of long COVID

R Perumal, L Shunmugam, K Naidoo, D Wilkins… - Iscience, 2023 - cell.com
As COVID-19 evolves from a pandemic to an endemic disease, the already staggering
number of people that have been or will be infected with SARS-CoV-2 is only destined to …