Life is constructed primarily using a toolbox of 20 canonical amino acids─ relying upon
these building blocks for the assembly of proteins and peptides that regulate nearly every …

Cancer remains the leading cause of death worldwide despite advances in treatment
options for patients. As such, safe and effective therapeutics are required. Short peptides …

Objectives Tirzepatide is a dual glucose-dependent insulinotropic polypeptide and glucagon-
like peptide-1 receptor agonist approved for type 2 diabetes. We performed a meta-analysis …

Incretin-based therapies with glucagon-like peptide-1 receptor agonists (GLP-1RA) are
already established in the treatment of type 2 diabetes (T2D). The development of novel …

Aim To perform a meta‐analysis to quantify the effect of tirzepatide on blood pressure and
lipids. Methods PubMed, Ovid/Medline, Web of Science, Scopus, Cochrane Library and …

Abstract Purpose of Review To highlight the added benefits of approved and upcoming,
centrally-acting, anti-obesity drugs, focusing not only on the most common metabolic and …

Glucagon-like peptide-1 receptor (GLP-1R) is a critical therapeutic target for type 2 diabetes
mellitus (T2DM). The GLP-1R cellular signaling mechanism relevant to insulin secretion and …

Diabetes is a chronic disease that affects a vast number of individuals globally, and without
optimal treatment, can lead to significant health complications. Moreover, obesity is another …

Nonalcoholic fatty liver disease (NAFLD) affects approximately 25% of the adult population
worldwide. This pathology can progress into end-stage liver disease with life-threatening …

Diabetes mellitus is a complex disorder characterized by insufficient insulin production or
insulin resistance, which results in a lifelong dependence on glucose-lowering drugs for …