Aim Immunosenescence is the decline of the host immune system due to aging, resulting in
various complications. The splenic lymphoid nodule is the pivotal compartment involved in …

The prevalence of urinary incontinence and other lower urinary tract symptoms (LUTS)
increases in association with increasing age. This effect is more noticeable in men after the …

While evolutionary explanations for aging have been widely acknowledged, the application
of evolutionary principles to the practice of aging research has, until recently, been limited …

Rats are a commonly used model for aging studies, and a frailty assessment tool for rats
would be of considerable value. There has been a recent focus on the development of …

Aging is a major risk factor for many chronic diseases, such as cancer, cardiovascular
disease, and diabetes. The exact mechanisms underlying the aging process are not fully …

It is not surprising that one of the most complex phenomena in nature is that of ageing. It
does not only bear biological interest, but it is also associated with cultural, psychological …

Expression of the transient receptor potential ankyrin 1 (TRPA1) receptor has been
demonstrated not only in the dorsal root and trigeminal ganglia but also in different brain …

Using longitudinal study data, we dynamically model how aging affects homeostasis in both
mice and humans. We operationalize homeostasis as a multivariate mean-reverting …

Achieving optimal health is an aspirational goal for the population, yet the definition of health
remains unclear. The role of nutrition in health has evolved beyond correcting malnutrition …

Age-associated changes in cardiac structure and function, together with estrogen loss,
contribute to the progression of heart failure with preserved ejection fraction in older women …