According to the Research Domain Criteria (RDoC), phenotypic differences among
disorders may be explained by variations in the nature and degree of neural circuitry …

Frailty is a clinical geriatric syndrome characterized by decreased multisystem function and
increased vulnerability to adverse outcomes. Although numerous studies have been …

Regulation of the epigenome is critical for healthy cell function but can become disrupted
with age, leading to aberrant epigenetic profiles including altered DNA methylation. Recent …

Human lifespan has increased significantly in the last 200 years, emphasizing our need to
age healthily. Insights into molecular mechanisms of aging might allow us to slow down its …

Abstract The Wake Forest nonhuman primate (NHP) Radiation Late Effects Cohort (RLEC) is
a unique and irreplaceable population of aging NHP radiation survivors which serves the …

Early detection and accurate diagnosis of Alzheimer's disease (AD) is essential for patient
care and disease treatment. Microfluidic technology is emerging as an economical and …

Functional independence is an important aspect of successful aging and differs with age
and by sex in humans. Physical performance often declines earlier than other age …

Background Height loss is associated with various health-related variables such as
cardiovascular disease, osteoporosis, cognitive function, and mortality. We hypothesized …

Due to the increasing focus on aging as an important risk factor for many serious diseases
and an emphasis on animal models that have translational value, an increasing number of …

随着全球老龄化日益严重, 衰老相关问题成了健康领域的一个研究热点. 近年来,
动物衰老模型得到广泛开发与应用, 在衰老机制研究中具有重要意义. 其中 …