The fission yeast Schizosaccharomyces pombe is an important model organism for the study
of eukaryotic molecular and cellular biology. Studies of S. pombe, together with studies of its …

The discovery that mutations in mitochondrial DNA (mtDNA) can be pathogenic in humans
has increased interest in understanding mtDNA maintenance. The functional state of mtDNA …

ABSTRACT Ribonuclease P (RNase P) is an ancient and essential endonuclease that
catalyses the cleavage of the 5′ leader sequence from precursor tRNAs (pre-tRNAs). The …

The eukaryotic endonucleases RNase P and RNase MRP require both RNA and protein
subunits for function. Even though the human RNase P and MRP RNAs were previously …

RNase MRP is a ribonucleoprotein (RNP) particle which is involved in the processing of pre‐
rRNA at site A 3 in internal transcribed spacer 1. Although RNase MRP has been analysed …

Eukaryotic RNase P and RNase MRP are endoribonucleases composed of RNA and protein
subunits. The RNA subunits of each enzyme share substantial secondary structural features …

Secondary structure is evaluated for determining evolutionary relationships between
catalytic RNA molecules that are so distantly related they are scarcely alignable. The …

RNase MRP is a ribonucleoprotein enzyme involved in processing precursor rRNA in
eukaryotes. To facilitate our structure–function analysis of RNase MRP from Saccharomyces …

Ribonuclease P is an ancient enzyme that cleaves pre‐tRNAs to generate mature 5'ends. It
contains an essential RNA subunit in Bacteria, Archaea, and Eukarya, but the degree to …

The Saccharomyces cerevisiae nuclear gene OXA1, which is conserved from prokaryotes to
human, was shown to be essential for cytochrome c oxidase and F1F0–ATP synthase …