Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Prolonged low-grade inflammation or smoldering inflammation is a hallmark of cancer. Mast
cells form a heterogeneous population of immune cells with differences in their ultra …

Mast cells are tissue-resident, innate immune cells that play a key role in the inflammatory
response and tissue homeostasis. Mast cells accumulate in the tumor stroma of different …

Gastric cancer is diagnosed in nearly one million new patients each year and it remains the
second leading cause of cancer-related deaths worldwide. Although gastric cancer …

The Kras gene is mutated to an oncogenic form in most pancreatic tumors. However, early
attempts to use this molecule as a specific biomarker of the disease, or inhibit its activity as a …

Mast cells in tissues are developed from mast cell progenitors emerging from the bone
marrow in a process highly regulated by transcription factors. Through the advancement of …

Pancreatic cancer (PC) is the most aggressive type of common cancers, and in 2014, nearly
40000 patients died from the disease in the United States. Pancreatic ductal …

Pancreatic ductal adenocarcinoma (PDAC) ranks fourth among cancer‐related deaths in the
United States. For patients with unresectable disease, treatment options are limited and lack …

Immune cells are important in the pathogenesis of acute pancreatitis and determine disease
severity. Results from cytokine-based clinical trials for acute pancreatitis have been …

Pancreatic stellate cells (PSCs) were identified in the early 1980s, but received much
attention after 1998 when the methods to isolate and culture them from murine and human …