In anamniote embryos, the major wave of zygotic genome activation starts during the mid-
blastula transition. However, some genes escape global genome repression, are activated …

Endogenous retroviruses (ERVs) contribute to∼ 10 percent of the mouse genome. They are
often silenced in differentiated somatic cells but differentially expressed at various …

Objective Human endogenous retroviruses have been implicated in neurodegenerative
diseases including amyotrophic lateral sclerosis (ALS). Expression of human endogenous …

It remains poorly understood about the regulation of gene and transposon transcription
during human early embryogenesis. Here, we report that broad H3K27ac domains are …

Characterization of Human Endogenous Retrovirus (HERV) expression within the
transcriptomic landscape using RNA-seq is complicated by uncertainty in fragment …

Our defenses against infection rely on the ability of the immune system to distinguish
invading pathogens from self. This task is exceptionally challenging, if not seemingly …

Dramatic nuclear reorganization occurs during early development to convert terminally
differentiated gametes to a totipotent zygote, which then gives rise to an embryo. Aberrant …

Transposable elements hold regulatory functions that impact cell fate determination by
controlling gene expression. However, little is known about the transcriptional machinery …

Inflammation is a common feature of all forms of chronic kidney disease; however, the
underlying mechanism remains poorly understood. Evolutionarily inherited endogenous …

Endogenous retroviruses (ERVs) are evolutionary remnants of retroviral infections in which
the viral genome became embedded as a dormant regulatory element within the host …