Colchicine is an ancient herbal drug derived from Colchicum autumnale. It was first used to
treat familial Mediterranean fever and gout. Based on its unique efficacy as an anti …

Carcinogenesis is a multistep process triggered by genetic alterations that activate different
signal transduction pathways and cause the progressive transformation of a normal cell into …

Bark protects the tree against environmental insults. Here, we analyzed whether this
defensive strategy could be utilized to broadly enhance protection against colitis. As a proof …

Transdifferentiation of epithelial cells into cells with mesenchymal properties and
appearance, that is, epithelial–mesenchymal transition (EMT), is essential during …

In recent years several drugs have been developed deriving from traditional products and
current drug research is actively investigating the possible therapeutic roles of many …

TGF‐β signaling pathway plays a key role in breast cancer metastasis. Recent studies
suggest that TGF‐β regulates tumor progression and invasion not only via transcriptional …

Review covering up to 07/2019 (−)-Parthenolide is a germacrane sesquiterpene lactone,
available in ample amounts from the traditional medical plant feverfew (Tanacetum …

Despite rapid advances in many fronts, pancreatic cancer (PC) remains one of the most
difficult human malignancies to treat due, in part, to de novo and acquired chemoresistance …

Oxidative stress, implicated in the etiology of cancer, results from an imbalance in the
production of reactive oxygen species (ROS) and cell's own antioxidant defenses. ROS …

Background Spermidine, a naturally occurring polyamine, displays a wide variety of internal
biological activities including cell growth and proliferation. However, the molecular …