[HTML][HTML] Pulmonary inhalation for disease treatment: Basic research and clinical translations

B Wang, L Wang, Q Yang, Y Zhang, T Qinglai, X Yang… - Materials Today Bio, 2024 - Elsevier
Pulmonary drug delivery has the advantages of being rapid, efficient, and well-targeted, with
few systemic side effects. In addition, it is non-invasive and has good patient compliance …

Biocompatible biodegradable polymeric nanocarriers in dry powder inhalers (DPIs) for pulmonary inhalation delivery

D Encinas-Basurto, BB Eedara… - Journal of Pharmaceutical …, 2024 - Springer
Background Pulmonary drug delivery is an efficient way to deliver drugs directly to the site of
action ie, lungs or to the blood circulation with minimum systemic effects. Recent emergence …

Engineering porous PLGA microparticles for pulmonary delivery of sildenafil citrate

REL Lazo, B de Paula Oliveira, A de Fátima Cobre… - Powder Technology, 2023 - Elsevier
Orally administered Sildenafil (SDF) is used to treat pulmonary arterial hypertension.
However, it has a relatively low bioavailability of approximately 40%. To circumvent such …

Inhalation dosage forms: a focus on dry powder inhalers and their advancements

S Magramane, K Vlahović, P Gordon, N Kállai-Szabó… - Pharmaceuticals, 2023 - mdpi.com
In this review, an extensive analysis of dry powder inhalers (DPIs) is offered, focusing on
their characteristics, formulation, stability, and manufacturing. The advantages of pulmonary …

Bacteria-based drug delivery for treating non-oncological diseases

Z Cao, Y Pang, J Pu, J Liu - Journal of Controlled Release, 2024 - Elsevier
Bacteria inhabit all over the human body, especially the skin, gastrointestinal tract,
respiratory tract, urogenital tract, as well as specific lesion sites, such as wound and tumor …

[HTML][HTML] Particulate bioaerogels for respiratory drug delivery

HY Li, C Makatsoris, B Forbes - Journal of Controlled Release, 2024 - Elsevier
The bioaerogel microparticles have been recently developed for respiratory drug delivery
and attract fast increasing interests. These highly porous microparticles have ultralow …

Preclinical evaluation of novel synthesised nanoparticles based on tyrosine poly (ester amide) for improved targeted pulmonary delivery

EZ Dahmash, NR Achkar, DK Ali, Q Jarrar, A Iyire… - Scientific Reports, 2024 - nature.com
Fixed dose combinations (FDCs) incorporating two or three medicines in a single inhaler
have been created to enhance patient compliance and hence clinical outcomes. However …

Development of Large Hollow Particles for Pulmonary Delivery of Cyclosporine A

Y Huang, H Tang, X Meng, Z Zhao, Y Liu, D Liu… - Pharmaceutics, 2023 - mdpi.com
The purpose of this study was to prepare large hollow particles (LHPs) by spray drying for
pulmonary delivery of cyclosporine A (CsA), using L-Leucine (LEU) and hydroxypropyl …

Recent advances in dosage form design for the elderly: a review

S Salave, P Patel, N Desai, D Rana… - Expert Opinion on …, 2023 - Taylor & Francis
Introduction With the increase in the elderly population and the prevalence of multiple
medical conditions, medication adherence, and efficacy have become crucial for the …

Simulating aerosol droplet dynamics and coalescence in tracheal intubation insights from a CFD-DEM analysis of PSAR tube interactions

H Lin, Y Jin, X Chen, J Xie, T Lu, Y Xu - Powder Technology, 2024 - Elsevier
This study employed the Computational Fluid Dynamics-Discrete Element Method (CFD-
DEM) to investigate targeted droplet delivery in tracheal intubation. Our findings reveal that …