Endothelial cells and mesenchymal cells are two different cell types with distinct
morphologies, phenotypes, functions, and gene profiles. Accumulating evidence, notably …

Endothelium is the largest organ in the body strategically located between the wall of blood
vessels and the blood stream. The human body contains approximately 1013 endothelial …

Introduction Embryogenesis is thought to be directed by a small number of signaling
pathways with most if not all embryonic signals having been identified. However, the …

Arteries and veins are specified by antagonistic transcriptional programs. However, during
development and regeneration, new arteries can arise from pre-existing veins through a …

Dysfunctional bone morphogenetic protein receptor-2 (BMPR2) signaling is implicated in the
pathogenesis of pulmonary arterial hypertension (PAH). We used a transcriptional high …

Coronary artery disease is the leading cause of death worldwide. Determining the coronary
artery developmental program could aid understanding of the disease and lead to new …

Pulmonary arterial hypertension (PAH) is characterized by vascular remodeling associated
with obliteration of pulmonary arterioles and formation of plexiform lesions composed of …

The recently discovered peptide apelin is known to be involved in the maintenance of insulin
sensitivity. However, questions persist regarding its precise role in the chronic setting …

Women with pulmonary arterial hypertension (PAH) exhibit better right ventricular (RV)
function and survival than men; however, the underlying mechanisms are unknown. We …

The mechanisms that promote the generation of new coronary vasculature during cardiac
homeostasis and after injury remain a fundamental and clinically important area of study in …