P-glycoprotein (P-gp) is crucial in the active transport of various substrates with diverse
structures out of cells, resulting in poor intestinal permeation and limited bioavailability …

Background The development of resistance is a problem shared by both classical
chemotherapy and targeted therapy. Patients may respond well at first, but relapse is …

Circumvention of cancer drug resistance is one of the major investigations in nanomedicine.
In this regard, nanotechnology-based drug delivery has offered various implications …

Ivermectin is a macrolide antiparasitic drug with a 16-membered ring that is widely used for
the treatment of many parasitic diseases such as river blindness, elephantiasis and scabies …

High-grade glioma is one of the most aggressive types of cancer with a low survival rate
ranging from 12 to 15 months after the first diagnosis. Though being the most common …

The intricate microstructure of the blood-brain barrier (BBB) is responsible for the accurate
intrinsic regulation of the central nervous system (CNS), in terms of neuronal …

The ATP-binding cassette (ABC) transporters P-glycoprotein (P-gp) and ABCG2 are
multidrug transporters that confer drug resistance to numerous anti-cancer therapeutics in …

Nanoformulations with advantages in drug delivery, safety and pharmacodynamics have
been booming as a promising strategy for cancer therapy. However, the traditional …

In the fight against cancer, early diagnosis is critical for effective treatment. Traditional
cancer diagnostic technologies, on the other hand, have limitations that make early …

Nature is the largest pharmacy in the world. Doxorubicin (DOX) and paclitaxel (PTX) are two
examples of natural-product-derived drugs employed as first-line treatment of various cancer …