Diabetes mellitus, energy metabolism, and COVID-19

C Conte, E Cipponeri, M Roden - Endocrine Reviews, 2024 - academic.oup.com
Obesity, diabetes mellitus (mostly type 2), and COVID-19 show mutual interactions because
they are not only risk factors for both acute and chronic COVID-19 manifestations, but also …

Cellular and molecular mechanisms of pathogenic and protective immune responses to SARS-CoV-2 and implications of COVID-19 vaccines

SMF Akbar, M Al Mahtab, S Khan - Vaccines, 2023 - mdpi.com
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection has devastated
the world with coronavirus disease 2019 (COVID-19), which has imparted a toll of at least …

A novel TWIK2 channel inhibitor binds at the bottom of the selectivity filter and protects against LPS-induced experimental endotoxemia in vivo

Y Zhi, X Wu, Y Chen, X Chen, X Chen, H Luo… - Biochemical …, 2023 - Elsevier
TWIK2 channel plays a critical role in NLRP3 inflammasome activation and mice deficient in
TWIK2 channel are protected from sepsis and inflammatory lung injury. However, inhibitors …

Multi-Algorithm Analysis Reveals Pyroptosis-Linked Genes as Pancreatic Cancer Biomarkers

K Wang, S Han, L Liu, L Zhao, I Herr - Cancers, 2024 - mdpi.com
Simple Summary Pancreatic ductal adenocarcinoma (PDAC) is often diagnosed at
advanced stages, resulting in limited treatment options and poor survival rates. To address …

Protection effects of mice liver and lung injury induced by coronavirus infection of Qingfei Paidu decoction involve inhibition of the NLRP3 signaling pathway

W Huang, X Chen, M Yin, J Li, M Luo, Y Ai, L Xie… - Journal of …, 2024 - Elsevier
Abstract Ethnopharmacological relevance Coronavirus Disease 2019 (COVID-19) is a grave
and pervasive global infectious malady brought about by Severe Acute Respiratory …

[PDF][PDF] Stimulation of PSTPIP1 to trigger proinflammatory responses in asymptomatic SARS-CoV-2 infections

R Ji, Y Wu, Y Ye, Y Li, Y Li, G Zhong, W Fan, C Feng… - Heliyon, 2024 - cell.com
Background A hyperinflammatory response to severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) infection gravely worsens the clinical progression of …

Bioinformatics and system biology analysis revealed the crosstalk between COVID‐19 and osteoarthritis

B Lai, H Jiang, T Liao, Y Gao… - … Inflammation and Disease, 2023 - Wiley Online Library
Background The global coronavirus disease 2019 (COVID‐19) outbreak has significantly
impacted public health. Moreover, there has been an association between the incidence …

Intranasal delivery of PEA-producing Lactobacillus paracasei F19 alleviates SARS-CoV-2 spike protein-induced lung injury in mice

A Del Re, SB Franzin, J Lu, I Palenca, A Zilli… - Translational Medicine …, 2024 - Springer
Background SARS-CoV-2 belongs to the coronaviridae family and infects human cells by
directly interacting with the angiotensin-converting enzyme-2 (ACE-2) through the viral …

[HTML][HTML] The inflammatory microenvironment of the lung at the time of infection governs innate control of SARS-CoV-2 replication

PJ Baker, AC Bohrer, E Castro, EP Amaral… - bioRxiv, 2024 - ncbi.nlm.nih.gov
SARS-CoV-2 infection leads to vastly divergent clinical outcomes ranging from
asymptomatic infection to fatal disease. Co-morbidities, sex, age, host genetics and vaccine …