Neurological diseases, particularly in the context of aging, have serious impacts on quality of
life and can negatively affect bone health. The brain-bone axis is critically important for …

As brain and bone disorders represent major health issues worldwide, substantial clinical
investigations demonstrated a bidirectional crosstalk on several levels, mechanistically …

Despite different operative and non-operative treatment regimens, the outcome after femoral
head fractures has changed little over the past decades. The initial trauma itself as well as …

Neurogenic heterotopic ossification (HO) is the ectopic formation of lamellar bone in non-
osseous tissues following traumatic brain or spinal cord injury. The associated complications …

Traumatic brain injury (TBI) leads to long-term cognitive, behavioral, affective deficits, and
increase neurodegenerative diseases. It is only in recent years that there is growing …

Background: Scientific evidence is mounting for an association between traumatic brain
injury and enhanced osteogenesis. The aim of this study was to correlate the in vitro …

Introduction Among many factors determining the outcome of complex fractures in
polytrauma patients, the role of traumatic brain injury (TBI) remains only partly understood …

Heterotopic ossification (HO) is a common complication in patients with coma after brain
injury. As the optimal timing of surgical resection is still controversial and unclear, a review of …

This study examines the effect of long‐term ICV administration of leptin in ewes. We found
that central application significantly decreased osteoblast activity as measured by serum …

A few studies have reported a relationship between leptin induced by brain injury and
healing of bone tissue. Our objective was to measure serum and callus leptin expression …