Principles and methods for transferring polygenic risk scores across global populations
Polygenic risk scores (PRSs) summarize the genetic predisposition of a complex human trait
or disease and may become a valuable tool for advancing precision medicine. However …
or disease and may become a valuable tool for advancing precision medicine. However …
Addressing the challenge of biomedical data inequality: An artificial intelligence perspective
Artificial intelligence (AI) and other data-driven technologies hold great promise to transform
healthcare and confer the predictive power essential to precision medicine. However, the …
healthcare and confer the predictive power essential to precision medicine. However, the …
A new method for multiancestry polygenic prediction improves performance across diverse populations
Polygenic risk scores (PRSs) increasingly predict complex traits; however, suboptimal
performance in non-European populations raise concerns about clinical applications and …
performance in non-European populations raise concerns about clinical applications and …
Quantifying portable genetic effects and improving cross-ancestry genetic prediction with GWAS summary statistics
Polygenic risk scores (PRS) calculated from genome-wide association studies (GWAS) of
Europeans are known to have substantially reduced predictive accuracy in non-European …
Europeans are known to have substantially reduced predictive accuracy in non-European …
Novel methods for multi-ancestry polygenic prediction and their evaluations in 5.1 million individuals of diverse ancestry
Polygenic risk scores are becoming increasingly predictive of complex traits, but their
suboptimal performance in non-European ancestry populations raises questions about their …
suboptimal performance in non-European ancestry populations raises questions about their …
Maternal and fetal origins of offspring blood pressure: statistical analysis using genetic correlation and genetic risk score-based Mendelian randomization
S Jin, T Wang, C Wenying, Y Wu… - International Journal …, 2023 - academic.oup.com
Background Epidemiological studies demonstrated that adverse in utero environment was
associated with increased risk of offspring high blood pressure, by using birthweight as the …
associated with increased risk of offspring high blood pressure, by using birthweight as the …
Transfer learning for classification of Alzheimer's disease based on genome wide data
Alzheimer's disease (AD) is a type of brain disorder that is regarded as a degenerative
disease because the corresponding symptoms aggravate with the time progression. Single …
disease because the corresponding symptoms aggravate with the time progression. Single …
MUSSEL: enhanced Bayesian polygenic risk prediction leveraging information across multiple ancestry groups
Polygenic risk scores (PRSs) are now showing promising predictive performance on a wide
variety of complex traits and diseases, but there exists a substantial performance gap across …
variety of complex traits and diseases, but there exists a substantial performance gap across …
A polygenic risk score for Alzheimer's disease constructed using APOE-region variants has stronger association than APOE alleles with mild cognitive impairment in …
Abstract Introduction Polygenic Risk Scores (PRSs) are summaries of genetic risk alleles for
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
an outcome. Methods We used summary statistics from five GWASs of AD to construct PRSs …
Benchmarking multi-ancestry prostate cancer polygenic risk scores in a real-world cohort
Y Shah, S Kulm, JT Nauseef, Z Chen… - PLOS Computational …, 2024 - journals.plos.org
Prostate cancer is a heritable disease with ancestry-biased incidence and mortality.
Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk …
Polygenic risk scores (PRSs) offer promising advancements in predicting disease risk …