Dietary plant polyphenols as the potential drugs in neurodegenerative diseases: current evidence, advances, and opportunities

L Yan, MS Guo, Y Zhang, L Yu, JM Wu… - Oxidative Medicine …, 2022 - Wiley Online Library
Neurodegenerative diseases, including Alzheimer's disease (AD), Parkinson's disease (PD),
and Huntington's disease (HD), are characterized by the progressive degeneration of …

[HTML][HTML] Oxidative stress, the blood–brain barrier and neurodegenerative diseases: The critical beneficial role of dietary antioxidants

J Feng, Y Zheng, M Guo, I Ares, M Martínez… - … Pharmaceutica Sinica B, 2023 - Elsevier
In recent years, growing awareness of the role of oxidative stress in brain health has
prompted antioxidants, especially dietary antioxidants, to receive growing attention as …

Neuroprotective effects of osmotin in Parkinson's disease-associated pathology via the AdipoR1/MAPK/AMPK/mTOR signaling pathways

JS Park, K Choe, HJ Lee, TJ Park, MO Kim - Journal of biomedical science, 2023 - Springer
Background Parkinson's disease (PD) is the second most frequent age-related
neurodegenerative disorder and is characterized by the loss of dopaminergic neurons. Both …

Caffeine may abrogate LPS-induced oxidative stress and neuroinflammation by regulating Nrf2/TLR4 in adult mouse brains

H Badshah, M Ikram, W Ali, S Ahmad, JR Hahm… - Biomolecules, 2019 - mdpi.com
Herein, we assayed the antioxidant and anti-inflammatory potential of caffeine in a
lipopolysaccharide (LPS)-injected mouse model of neurodegeneration and synaptic …

Natural dietary supplementation of curcumin protects mice brains against ethanol-induced oxidative stress-mediated neurodegeneration and memory impairment via …

M Ikram, K Saeed, A Khan, T Muhammad, MS Khan… - Nutrients, 2019 - mdpi.com
The aim of the current study was to explore the underlying neuroprotective mechanisms of
curcumin (50 mg/kg, for six weeks) against ethanol (5 mg/kg ip, for six weeks) induced …

17β-estradiol modulates SIRT1 and halts oxidative stress-mediated cognitive impairment in a male aging mouse model

M Khan, R Ullah, SU Rehman, SA Shah, K Saeed… - Cells, 2019 - mdpi.com
Oxidative stress has been considered the main mediator in neurodegenerative disease and
in normal aging processes. Several studies have reported that the accumulation of reactive …

Inhibition of the ISR abrogates mGluR5-dependent long-term depression and spatial memory deficits in a rat model of Alzheimer's disease

Z Hu, P Yu, Y Zhang, Y Yang, M Zhu, S Qin… - Translational …, 2022 - nature.com
Soluble amyloid-β-protein (Aβ) oligomers, a major hallmark of AD, trigger the integrated
stress response (ISR) via multiple pathologies including neuronal hyperactivation …

Systematic review of the common pathophysiological mechanisms in COVID-19 and neurodegeneration: the role of bioactive compounds and natural antioxidants

K Choe, HY Park, M Ikram, HJ Lee, TJ Park, R Ullah… - Cells, 2022 - mdpi.com
The novel coronavirus (2019-nCoVCOVID-19) belongs to the Beta coronavirus family, which
contains MERS-CoV (Middle East respiratory syndrome coronavirus) and SARS-CoV …

Oxidative stress in non-alcoholic fatty liver disease

C Smirne, E Croce, D Di Benedetto, V Cantaluppi… - Livers, 2022 - mdpi.com
Non-alcoholic fatty liver disease (NAFLD) is a challenging disease caused by multiple
factors, which may partly explain why it still remains an orphan of adequate therapies. This …

Neuroprotective Effects of Trilobatin, a Novel Naturally Occurring Sirt3 Agonist from Lithocarpus polystachyus Rehd., Mitigate Cerebral Ischemia/Reperfusion Injury …

J Gao, N Chen, N Li, F Xu, W Wang, Y Lei… - Antioxidants & redox …, 2020 - liebertpub.com
Aims: Neuroinflammation and oxidative stress are deemed the prime causes of brain injury
after cerebral ischemia/reperfusion (I/R). Since the silent mating-type information regulation …