Nicotinamide (NAM) is the amide form of niacin and an important precursor of nicotinamide
adenine dinucleotide (NAD), which is needed for energy metabolism and cellular functions …

Alzheimer's disease (AD) is a common cause of dementia that is clinically characterized by
the loss of memory and cognitive functions. Currently, there is no specific cure for the …

Microglia are permanent immune cells of the central nervous system. Microglia play an
important role in the pathological process of Alzheimer's disease (AD). They are mainly …

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive
memory loss and cognitive decline. Although substantial research has been conducted to …

Diabetes-associated affective disorders are of wide concern, and oxidative stress plays a
vital role in the pathological process. This study was to investigate the cerebroprotective …

Neuroinflammation is a critical feature in the pathogenesis of neurodegenerative disorders
such as Alzheimer's disease (AD). Hesperetin can exert anti-inflammatory, antioxidant and …

Sepsis is a severe inflammatory condition that can cause organ dysfunction, including acute
kidney injury (AKI). Hesperetin is a flavonoid aglycone that has potent antioxidant and anti …

Neurodegenerative disorders are characterized by mitochondrial dysfunction and
subsequently oxidative stress, inflammation, and apoptosis that contribute to neuronal …

Neurodegenerative diseases affect millions of people worldwide. Regardless of the
underlying cause, neuroinflammation is the greatest risk factor for developing any of these …

The transcription factor Nrf2 (nuclear factor-erythroid 2 p45-related factor 2) play a crucial
role in cellular redox and metabolic system. Activation of Nrf2 may be an effective …