Oxidative stress has been considered as the main mediator in neurodegenerative diseases.
A high-fat diet (HFD) and metabolic diseases result in oxidative stress generation, leading to …

Alzheimer's disease (AD) is a central neurodegenerative disease generally among the
elderly; it accounts for approximately 50–75% of total cases of dementia patients and poses …

The prevalence of both Alzheimer's disease (AD) and diabetes mellitus is increasing with
the societies' aging and has become an essential social concern worldwide. Accumulation …

Background In the central nervous system (CNS) myelin sheaths stabilize, protect, and
electrically insulate axons. However, in demyelinating autoimmune CNS diseases such as …

Cadmium (Cd) is a major environmental contaminant that has been linked to oocyte quality
reduction and early embryo mortality in various in vivo studies. In this study, we investigated …

This study aimed to determine whether hesperetin (HPT) has chondroprotective effects
against the TNF-α-induced inflammatory response of chondrocytes and related mechanisms …

Depression is one of the most common mental health disorders and it is generally
characterized by negative mood. Although electroconvulsive therapy (ECT) is an effective …

Thoracic aortic aneurysm and dissection (TAAD) is a lethal cardiovascular condition without
effective pharmaceutical therapy. Identifying novel drugs that target the key pathogenetic …

Diabetes Mellitus is accompanied by chronic hyperglycemia, inflammation, and related
molecular processes, which leads to diabetic neuropathy. In this work, we tested Thiadiazine …

Abstract Ischemia/hypoxia (I/H)‐induced myocardial injury has a large burden worldwide.
Hesperetin (HSP) has a cardioprotective effect, but the molecular mechanism underlying this …