The synaptic hypothesis of schizophrenia version III: a master mechanism
OD Howes, EC Onwordi - Molecular Psychiatry, 2023 - nature.com
The synaptic hypothesis of schizophrenia has been highly influential. However, new
approaches mean there has been a step-change in the evidence available, and some tenets …
approaches mean there has been a step-change in the evidence available, and some tenets …
Towards a youth mental health paradigm: a perspective and roadmap
Most mental disorders have a typical onset between 12 and 25 years of age, highlighting the
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
importance of this period for the pathogenesis, diagnosis, and treatment of mental ill-health …
Neuroimaging in schizophrenia: an overview of findings and their implications for synaptic changes
OD Howes, C Cummings, GE Chapman… - …, 2023 - nature.com
Over the last five decades, a large body of evidence has accrued for structural and metabolic
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
brain alterations in schizophrenia. Here we provide an overview of these findings, focusing …
Inflammation and brain structure in schizophrenia and other neuropsychiatric disorders: a Mendelian randomization study
Importance Previous in vitro and postmortem research suggests that inflammation may lead
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
to structural brain changes via activation of microglia and/or astrocytic dysfunction in a range …
Cross disorder comparisons of brain structure in schizophrenia, bipolar disorder, major depressive disorder, and 22q11. 2 deletion syndrome: a review of ENIGMA …
This review compares the main brain abnormalities in schizophrenia (SZ), bipolar disorder
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
(BD), major depressive disorder (MDD), and 22q11. 2 Deletion Syndrome (22q11DS) …
Schizophrenia: a developmental disorder with a risk of non-specific but avoidable decline
The onset of schizophrenia is determined by biological and social risk factors operating
predominantly during development. These result in subtle deviations in brain structure and …
predominantly during development. These result in subtle deviations in brain structure and …
Cortical and subcortical neuroanatomical signatures of schizotypy in 3004 individuals assessed in a worldwide ENIGMA study
M Kirschner, B Hodzic-Santor, M Antoniades… - Molecular …, 2022 - nature.com
Neuroanatomical abnormalities have been reported along a continuum from at-risk stages,
including high schizotypy, to early and chronic psychosis. However, a comprehensive …
including high schizotypy, to early and chronic psychosis. However, a comprehensive …
Normative modeling of brain morphometry in clinical high risk for psychosis
Importance The lack of robust neuroanatomical markers of psychosis risk has been
traditionally attributed to heterogeneity. A complementary hypothesis is that variation in …
traditionally attributed to heterogeneity. A complementary hypothesis is that variation in …
Hippocampal circuit dysfunction in psychosis
Despite strong evidence of the neurodevelopmental origins of psychosis, current
pharmacological treatment is not usually initiated until after a clinical diagnosis is made, and …
pharmacological treatment is not usually initiated until after a clinical diagnosis is made, and …
Application of a machine learning algorithm for structural brain images in chronic schizophrenia to earlier clinical stages of psychosis and autism spectrum disorder: a …
Y Zhu, H Nakatani, W Yassin, N Maikusa… - Schizophrenia …, 2022 - academic.oup.com
Abstract Background and Hypothesis Machine learning approaches using structural
magnetic resonance imaging (MRI) can be informative for disease classification; however …
magnetic resonance imaging (MRI) can be informative for disease classification; however …