Intrarenal autoregulatory mechanisms maintain renal blood flow (RBF) and glomerular
filtration rate (GFR) independent of renal perfusion pressure (RPP) over a defined range (80 …

Recent studies have indicated that arachidonic acid is primarily metabolized by cytochrome
P-450 (CYP) enzymes in the brain, lung, kidney, and peripheral vasculature to 20 …

Providing a comprehensive review of reactions of oxidation for different classes of organic
compounds and polymers, and biological processes mediated by free radicals, Oxidation …

The endothelium, a monolayer of endothelial cells, constitutes the inner cellular lining of the
blood vessels (arteries, veins and capillaries) and the lymphatic system, and therefore is in …

Nitric oxide (NO) is a multi-faceted molecule with dichotomous regulatory roles in many
areas of biology. The complexity of its biological effects is a consequence of its numerous …

The free radical nitric oxide (NO) has emerged in recent years as a fundamental signaling
molecule for the maintenance of homeostasis, as well as a potent cytotoxic effector involved …

Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize
arachidonic acid to substances which affect arterial tone, it has become increasingly clear …

The three subtypes of calcium‐activated potassium channels (KCa) of large, intermediate
and small conductance (BKCa, IKCa and SKCa) are present in the vascular wall. In healthy …

In the brain, pressure-induced myogenic constriction of cerebral arteriolar muscle
contributes to autoregulation of cerebral blood flow (CBF). This study examined the role of …

The cerebrovascular endothelium exerts a profound influence on cerebral vessels and
cerebral blood flow. This review summarizes current knowledge of various dilator and …