The kidney has the highest abundance of cytochrome P-450 of all extrahepatic organs.
Within the kidney, the highest concentration of cytochrome P-450 is found in the proximal …

Coronary collateral growth (CCG) is impaired in metabolic syndrome (MetS). microRNA-145
(miR-145-Adv) delivery to our rat model of MetS (JCR) completely restored and neutrophil …

Renal function is perturbed by inhibition of nitric oxide synthase (NOS). To probe the basis of
this effect, we characterized the effects of nitric oxide (NO), a known suppressor of …

This study examined the response to nitric oxide (NO) in rat middle cerebral arteries (MCA).
NO donors increased the activity of a 205-pS K+ channel recorded from vascular smooth …

We have previously demonstrated that a stable synthetic analog of 20-
hydroxyeicosatetraenoic acid (20-HETE), N-[20-hydroxyeicosa-5 (Z), 14 (Z)-dienoyl] glycine …

The discovery of the anti-inflammatory effects of corticosteroid hormones by Philip Hench
and colleagues in 1929 revolutionized the treatments of various inflammatory conditions …

The nitric oxide (NO)/cGMP pathway in the vascular smooth muscle cell (VSMC) is an
important cellular signaling system for the regulation of VSMC relaxation. We present a …

Role of 20-hydroxyeicosatetraenoic acid and epoxyeicosatrien... : Current Opinion in
Nephrology and Hypertension Role of 20-hydroxyeicosatetraenoic acid and …

Background and Purpose—The present study examined the contributions of a rise in cGMP
versus a fall in 20-HETE levels to the vasodilator response to nitric oxide (NO) in the …

Cerebral blood flow adequate for brain activity and metabolic demand is maintained through
the processes of autoregulation and neurovascular coupling. Astrocytes undoubtedly make …