Order and disorder control the functional rearrangement of influenza hemagglutinin
Influenza hemagglutinin (HA), a homotrimeric glycoprotein crucial for membrane fusion,
undergoes a large-scale structural rearrangement during viral invasion. X-ray …
undergoes a large-scale structural rearrangement during viral invasion. X-ray …
Is it possible to develop a “universal” influenza virus vaccine? Immunogenetic considerations underlying B-cell biology in the development of a pan-subtype influenza …
SF Andrews, BS Graham… - Cold Spring …, 2018 - cshperspectives.cshlp.org
Current influenza vaccines preferentially generate B-cell responses to the variable
hemagglutinin (HA) head. Focusing vaccine-induced antibody responses on epitopes in the …
hemagglutinin (HA) head. Focusing vaccine-induced antibody responses on epitopes in the …
Cell-free expression of a therapeutic protein serratiopeptidase
Y Meng, M Yang, W Liu, J Li - Molecules, 2023 - mdpi.com
Serratiopeptidase is a clinical therapeutic protein for the treatment of human diseases such
as arthritis, bronchitis, and thrombosis. Yet production of this protein in a heterologous host …
as arthritis, bronchitis, and thrombosis. Yet production of this protein in a heterologous host …
Cell‐free protein synthesis enables one‐pot cascade biotransformation in an aqueous‐organic biphasic system
Biocatalytic cascade reactions have become increasingly important and useful for chemical
synthesis. However, biocatalysts are often incompatible with organic solvents, which …
synthesis. However, biocatalysts are often incompatible with organic solvents, which …
Development of molecular clamp stabilized hemagglutinin vaccines for Influenza A viruses
CLD McMillan, STM Cheung, N Modhiran, J Barnes… - npj Vaccines, 2021 - nature.com
Influenza viruses cause a significant number of infections and deaths annually. In addition to
seasonal infections, the risk of an influenza virus pandemic emerging is extremely high …
seasonal infections, the risk of an influenza virus pandemic emerging is extremely high …
Design and structure of an engineered disulfide-stabilized influenza virus hemagglutinin trimer
We engineered a disulfide-stabilized influenza virus hemagglutinin (HA) trimer, termed HA3-
SS, by introducing cysteine residues into the HA stem to covalently bridge the three …
SS, by introducing cysteine residues into the HA stem to covalently bridge the three …
Targeting viral surface proteins through structure-based design
The emergence of novel viral infections of zoonotic origin and mutations of existing human
pathogenic viruses represent a serious concern for public health. It warrants the …
pathogenic viruses represent a serious concern for public health. It warrants the …
Structural and biophysical characterizations of HIV-1 matrix trimer binding to lipid nanodiscs shed light on virus assembly
RE Murphy, AB Samal, J Vlach, V Mas… - Journal of Biological …, 2019 - ASBMB
During the late phase of the HIV-1 replication cycle, the viral Gag polyproteins are targeted
to the plasma membrane for assembly. The Gag-membrane interaction is mediated by …
to the plasma membrane for assembly. The Gag-membrane interaction is mediated by …
[HTML][HTML] Identification of broad-spectrum neutralizing antibodies against influenza A virus and evaluation of their prophylactic efficacy in mice
S Son, SB Ahn, G Kim, Y Jang, C Ko, M Kim, SJ Kim - Antiviral Research, 2023 - Elsevier
Influenza A virus continuously infects humans and the antigenic shifts of this respiratory virus
enable it to cross the species barrier, threatening public health with the risk of pandemics …
enable it to cross the species barrier, threatening public health with the risk of pandemics …
Rapid Generation of Therapeutic Nanoparticles Using Cell‐Free Expression Systems
The surface modification of membrane‐based nanoparticles, such as liposomes,
polymersomes, and lipid nanoparticles, with targeting molecules, such as binding proteins …
polymersomes, and lipid nanoparticles, with targeting molecules, such as binding proteins …