Next-generation TB vaccines: progress, challenges, and prospects

L Zhuang, Z Ye, L Li, L Yang, W Gong - Vaccines, 2023 - mdpi.com
Tuberculosis (TB), caused by Mycobacterium tuberculosis (MTB), is a prevalent global
infectious disease and a leading cause of mortality worldwide. Currently, the only available …

Progress and prospects on vaccine development against monkeypox infection

MJ Saadh, T Ghadimkhani, N Soltani… - Microbial …, 2023 - Elsevier
The monkeypox virus (MPOX) is an uncommon zoonotic illness brought on by an
orthopoxvirus (OPXV). MPOX can occur with symptoms similar to smallpox. Since April 25 …

Immunogenic proteins and potential delivery platforms for mpox virus vaccine development: a rapid review

Y Wang, K Yang, H Zhou - International Journal of Biological …, 2023 - Elsevier
Since May 2022, the mpox virus (MPXV) has spread worldwide and become a potential
threat to global public health. Vaccines are important tools for preventing MPXV …

A comprehensive approach to developing a multi-epitope vaccine against Mycobacterium tuberculosis: from in silico design to in vitro immunization evaluation

F Jiang, Y Han, Y Liu, Y Xue, P Cheng, L Xiao… - Frontiers in …, 2023 - frontiersin.org
Introduction The Bacillus Calmette-Guérin (BCG) vaccine, currently used against
tuberculosis (TB), exhibits inconsistent efficacy, highlighting the need for more potent TB …

PP19128R, a Multiepitope Vaccine Designed to Prevent Latent Tuberculosis Infection, Induced Immune Responses In Silico and In Vitro Assays

F Jiang, C Peng, P Cheng, J Wang, J Lian, W Gong - Vaccines, 2023 - mdpi.com
Background: Latent tuberculosis infection (LTBI) is the primary source of active tuberculosis
(ATB), but a preventive vaccine against LTBI is lacking. Methods: In this study, dominant …

Designing a multi-epitope vaccine to control porcine epidemic diarrhea virus infection using immunoinformatics approaches

W Hou, H Wu, S Wang, W Wang, B Wang… - Frontiers in …, 2023 - frontiersin.org
Porcine epidemic diarrhea virus (PEDV), a continuously evolving pathogen, causes severe
diarrhea in piglets with high mortality rates. However, current vaccines cannot provide …

In silico design of a broad-spectrum multiepitope vaccine against influenza virus

L Yuan, X Li, M Li, R Bi, Y Li, J Song, W Li… - International Journal of …, 2024 - Elsevier
Influenza remains a global health concern due to its potential to cause pandemics as a
result of rapidly mutating influenza virus strains. Existing vaccines often struggle to keep up …

Reverse engineering protection: A comprehensive survey of reverse vaccinology-based vaccines targeting viral pathogens

S Ponne, R Kumar, SM Vanmathi, RSN Brilhante… - Vaccine, 2024 - Elsevier
Vaccines have significantly reduced the impact of numerous deadly viral infections.
However, there is an increasing need to expedite vaccine development in light of the …

Developing a multi-epitope vaccine candidate to combat porcine epidemic diarrhea virus and porcine deltacoronavirus co-infection by employing an …

W Hou, H Wu, W Wang, R Wang, W Han… - Frontiers in …, 2023 - frontiersin.org
Coinfection of porcine epidemic diarrhea virus (PEDV) and porcine deltacoronavirus
(PDCoV) is common in pig farms, but there is currently no effective vaccine to prevent this co …

[HTML][HTML] Construction and application of adenoviral vectors

H Zhang, H Wang, Y An, Z Chen - Molecular Therapy. Nucleic …, 2023 - ncbi.nlm.nih.gov
Adenoviral vectors have been widely used as vaccine candidates or potential vaccine
candidates against infectious diseases due to the convenience of genome manipulation …