The advent of human induced pluripotent stem cell (hiPSC) technology has revitalized the
efforts in the past decade to realize more fully the potential of human embryonic stem cells …

It has been suggested that deficient protein trafficking to the cell membrane is the dominant
mechanism associated with type 2 Long QT syndrome (LQT2) caused by Kv11. 1 potassium …

Patient‐specific induced pluripotent stem cells (iPSCs) will assist research on genetic
cardiac maladies if the disease phenotype is recapitulated in vitro. However, genetic …

Background: The long QT syndrome (LQTS) is an arrhythmogenic disorder of QT interval
prolongation that predisposes patients to life-threatening ventricular arrhythmias such as …

Life threatening ventricular arrhythmias leading to sudden cardiac death are a major cause
of morbidity and mortality. In the absence of structural heart disease, these arrhythmias …

In the last decade, the generation of cardiac disease models based on human-induced
pluripotent stem cells (hiPSCs) has become of common use, providing new opportunities to …

Background: Type 1 long QT syndrome (LQT1) is caused by loss-of-function variants in the
KCNQ1-encoded Kv7. 1 potassium channel α-subunit that is essential for cardiac …

Human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) are the most promising
source of cardiomyocytes (CMs) for experimental and clinical applications, but their use is …

Mutations in the gene encoding the enzyme tafazzin, TAZ, cause Barth syndrome (BTHS).
Individuals with this X-linked multisystem disorder present cardiomyopathy (CM)(often …

Human induced pluripotent stem cells (hiPSCs) have revolutionized the field of human
disease modeling, with an enormous potential to serve as paradigm shifting platforms for …