Asymmetric organocatalysis: an enabling technology for medicinal chemistry

B Han, XH He, YQ Liu, G He, C Peng… - Chemical Society Reviews, 2021 - pubs.rsc.org
The efficacy and synthetic versatility of asymmetric organocatalysis have contributed
enormously to the field of organic synthesis since the early 2000s. As asymmetric …

Tricyclic sesquiterpenes from marine origin

F Le Bideau, M Kousara, L Chen, L Wei… - Chemical …, 2017 - ACS Publications
The structure elucidation, biosynthesis, and biological activity of marine carbotricyclic
sesquiterpene compounds are reviewed from the pioneering results to the end of 2015 …

Fungi from marine sponges: diversity, biological activity and secondary metabolites

U Höller, AD Wright, GF Matthee, GM Konig… - Mycological …, 2000 - cambridge.org
The diversity, biological activity and secondary metabolite production of fungi associated
with marine sponges were investigated in order to assess the potential of these fungi for the …

[图书][B] Marine chemical ecology

JB McClintock, BJ Baker - 2001 - taylorfrancis.com
The interdisciplinary field of marine chemical ecology is an expanding and dynamic science.
It is no surprise that the breadth of marine organisms studied expanded in concert with …

In vivo antimalarial activity of the beta-carboline alkaloid manzamine A

KKH Ang, MJ Holmes, T Higa… - Antimicrobial agents …, 2000 - Am Soc Microbiol
Manzamine A, a β-carboline alkaloid present in several marine sponge species, inhibits the
growth of the rodent malaria parasite Plasmodium berghei in vivo. More than 90% of the …

[图书][B] Bioactive compounds from natural sources: isolation, characterization and biological properties

C Tringali - 2000 - taylorfrancis.com
Interest in obtaining biologically active compounds from natural sources has recently spiked
due to their low toxicity, complete biodegradability, availability from renewable sources, and …

In vitro and In vivo evaluation of betulinic acid as an antimalarial

JCP Steele, DC Warhurst, GC Kirby… - … Journal Devoted to …, 1999 - Wiley Online Library
The lupane-type triterpene betulinic acid was isolated from an ethanol extract of the root
bark of the Tanzanian tree Uapaca nitida Müll-Arg.(Euphorbiaceæ). The in vitro …

Chemical defenses: from compounds to communities

VJ Paul, KE Arthur, R Ritson-Williams… - The Biological …, 2007 - journals.uchicago.edu
Marine natural products play critical roles in the chemical defense of many marine
organisms and in some cases can influence the community structure of entire ecosystems …

Biodiversity as a source of anticancer drugs

G Tan, C Gyllenhaal, DD Soejarto - Current drug targets, 2006 - ingentaconnect.com
Natural Products have been the most significant source of drugs and drug leads in history.
Their dominant role in cancer chemotherapeutics is clear with about 74% of anticancer …

Enantio‐and diastereoselective construction of α, α‐disubstituted α‐amino acids for the synthesis of biologically active compounds

Y Ohfune, T Shinada - European journal of organic chemistry, 2005 - Wiley Online Library
Natural and unnatural compounds possessing an α, α‐disubstituted α‐amino acid
substructure have received significant attention because of their structural complexity and …