The Story of RNA Unfolded: The Molecular Function of DEAD-and DExH-Box ATPases and Their Complex Relationship with Membraneless Organelles
K Dörner, M Hondele - Annual Review of Biochemistry, 2024 - annualreviews.org
DEAD-and DExH-box ATPases (DDX/DHXs) are abundant and highly conserved cellular
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
enzymes ubiquitously involved in RNA processing. By remodeling RNA–RNA and RNA …
Eukaryotic Ribosome Assembly
A Vanden Broeck, S Klinge - Annual Review of Biochemistry, 2024 - annualreviews.org
During the last ten years, developments in cryo–electron microscopy have transformed our
understanding of eukaryotic ribosome assembly. As a result, the field has advanced from a …
understanding of eukaryotic ribosome assembly. As a result, the field has advanced from a …
The RNA helicase Dbp10 coordinates assembly factor association with PTC maturation during ribosome biogenesis
V Mitterer, H Hamze, N Kunowska, U Stelzl… - Nucleic Acids …, 2024 - academic.oup.com
During ribosome biogenesis a plethora of assembly factors and essential enzymes drive the
unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase …
unidirectional maturation of nascent pre-ribosomal subunits. The DEAD-box RNA helicase …
Crossing boundaries of light microscopy resolution discerns novel assemblies in the nucleolus
CC Correll, U Rudloff, JD Schmit, DA Ball… - Histochemistry and Cell …, 2024 - Springer
The nucleolus is the largest membraneless organelle and nuclear body in mammalian cells.
It is primarily involved in the biogenesis of ribosomes, essential macromolecular machines …
It is primarily involved in the biogenesis of ribosomes, essential macromolecular machines …
Human RPF1 and ESF1 in Pre-rRNA Processing and the Assembly of Pre-Ribosomal Particles: A Functional Study
A Deryabin, A Moraleva, K Dobrochaeva, D Kovaleva… - Cells, 2024 - mdpi.com
Ribosome biogenesis is essential for the functioning of living cells. In higher eukaryotes, this
multistep process is tightly controlled and involves a variety of specialized proteins and …
multistep process is tightly controlled and involves a variety of specialized proteins and …
The DEAD-box ATPase Dbp10/DDX54 initiates peptidyl transferase center formation during 60S ribosome biogenesis
DEAD-box ATPases play crucial roles in guiding rRNA restructuring events during the
biogenesis of large (60S) ribosomal subunits, but their precise molecular functions are …
biogenesis of large (60S) ribosomal subunits, but their precise molecular functions are …
Heterogeneity of chemical modifications on RNA
WSS Goh, Y Kuang - Biophysical Reviews, 2024 - Springer
The chemical modifications of RNAs broadly impact almost all cellular events and influence
various diseases. The rapid advance of sequencing and other technologies opened the …
various diseases. The rapid advance of sequencing and other technologies opened the …
Structural insights into coordinating 5S RNP rotation with ITS2 pre‐RNA processing during ribosome formation
M Thoms, B Lau, J Cheng, L Fromm, T Denk… - EMBO …, 2023 - embopress.org
The rixosome defined in Schizosaccharomyces pombe and humans performs diverse roles
in pre‐ribosomal RNA processing and gene silencing. Here, we isolate and describe the …
in pre‐ribosomal RNA processing and gene silencing. Here, we isolate and describe the …
Yeast ribosome biogenesis factors Puf6 and Nog2 and ribosomal proteins uL2 and eL43 act in concert to facilitate the release of nascent large ribosomal subunits …
AJ LaPeruta, S Hedayati, J Micic… - Nucleic Acids …, 2023 - academic.oup.com
Large ribosomal subunit precursors (pre-LSUs) are primarily synthesized in the nucleolus.
At an undetermined step in their assembly, they are released into the nucleoplasm …
At an undetermined step in their assembly, they are released into the nucleoplasm …
The Role of Ribosomal Proteins eL15 and eL36 in the Early Steps of Yeast 60S Ribosomal Subunit Assembly
J Fernández-Fernández, S Martín-Villanueva… - Journal of Molecular …, 2023 - Elsevier
Ribosomal proteins have important roles in maintaining the structure and function of mature
ribosomes, but they also drive crucial rearrangement reactions during ribosome biogenesis …
ribosomes, but they also drive crucial rearrangement reactions during ribosome biogenesis …