Advances in the treatment of Parkinson's disease
Parkinson's disease (PD) affects one in every 100 persons above the age of 65 years,
making it the second most common neurodegenerative disease after Alzheimer's disease …
making it the second most common neurodegenerative disease after Alzheimer's disease …
Pluripotent stem cell-based therapy for Parkinson's disease: Current status and future prospects
Parkinson's disease (PD) is one of the most common neurodegenerative disorders, which
affects about 0.3% of the general population. As the population in the developed world ages …
affects about 0.3% of the general population. As the population in the developed world ages …
An RNA code for the FOX2 splicing regulator revealed by mapping RNA-protein interactions in stem cells
The elucidation of a code for regulated splicing has been a long-standing goal in
understanding the control of post-transcriptional gene expression events that are crucial for …
understanding the control of post-transcriptional gene expression events that are crucial for …
Direct reprogramming of genetically unmodified fibroblasts into pluripotent stem cells
A Meissner, M Wernig, R Jaenisch - Nature biotechnology, 2007 - nature.com
In vitro reprogramming of somatic cells into a pluripotent embryonic stem cell–like state has
been achieved through retroviral transduction of murine fibroblasts with Oct4, Sox2, c-myc …
been achieved through retroviral transduction of murine fibroblasts with Oct4, Sox2, c-myc …
Transplantation of human neural stem cells exerts neuroprotection in a rat model of Parkinson's disease
T Yasuhara, N Matsukawa, K Hara, G Yu… - Journal of …, 2006 - Soc Neuroscience
Neural stem cells (NSCs) possess high potencies of self-renewal and neuronal
differentiation. We explored here whether transplantation of human NSCs cloned by v-myc …
differentiation. We explored here whether transplantation of human NSCs cloned by v-myc …
Progress in Parkinson's disease—where do we stand?
A Toulouse, AM Sullivan - Progress in neurobiology, 2008 - Elsevier
Parkinson's disease was first described in 1817 by James Parkinson. It is one of the most
common neurodegenerative disorders, affecting the nigrostriatal pathways involved in the …
common neurodegenerative disorders, affecting the nigrostriatal pathways involved in the …
Enhanced yield of neuroepithelial precursors and midbrain-like dopaminergic neurons from human embryonic stem cells using the bone morphogenic protein …
KC Sonntag, J Pruszak, T Yoshizaki… - Stem …, 2007 - academic.oup.com
It is currently not known whether dopamine (DA) neurons derived from human embryonic
stem cells (hESCs) can survive in vivo and alleviate symptoms in models of Parkinson …
stem cells (hESCs) can survive in vivo and alleviate symptoms in models of Parkinson …
Alternative splicing events identified in human embryonic stem cells and neural progenitors
Human embryonic stem cells (hESCs) and neural progenitor (NP) cells are excellent models
for recapitulating early neuronal development in vitro, and are key to establishing strategies …
for recapitulating early neuronal development in vitro, and are key to establishing strategies …
Human embryonic stem cell-derived neurons adopt and regulate the activity of an established neural network
JP Weick, Y Liu, SC Zhang - Proceedings of the National …, 2011 - National Acad Sciences
Whether hESC-derived neurons can fully integrate with and functionally regulate an existing
neural network remains unknown. Here, we demonstrate that hESC-derived neurons …
neural network remains unknown. Here, we demonstrate that hESC-derived neurons …
Functional control of transplantable human ESC-derived neurons via optogenetic targeting
Current methods to examine and regulate the functional integration and plasticity of human
ESC (hESC)-derived neurons are cumbersome and technically challenging. Here, we …
ESC (hESC)-derived neurons are cumbersome and technically challenging. Here, we …