[HTML][HTML] Artificial intelligence in cancer target identification and drug discovery
Artificial intelligence is an advanced method to identify novel anticancer targets and discover
novel drugs from biology networks because the networks can effectively preserve and …
novel drugs from biology networks because the networks can effectively preserve and …
[HTML][HTML] The foundation and architecture of precision medicine in neurology and psychiatry
Neurological and psychiatric diseases have high degrees of genetic and pathophysiological
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
heterogeneity, irrespective of clinical manifestations. Traditional medical paradigms have …
[HTML][HTML] Large-scale deep multi-layer analysis of Alzheimer's disease brain reveals strong proteomic disease-related changes not observed at the RNA level
The biological processes that are disrupted in the Alzheimer's disease (AD) brain remain
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
incompletely understood. In this study, we analyzed the proteomes of more than 1,000 brain …
[HTML][HTML] Tau interactome maps synaptic and mitochondrial processes associated with neurodegeneration
Tau (MAPT) drives neuronal dysfunction in Alzheimer disease (AD) and other tauopathies.
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …
To dissect the underlying mechanisms, we combined an engineered ascorbic acid …
Large-scale proteomic analysis of Alzheimer's disease brain and cerebrospinal fluid reveals early changes in energy metabolism associated with microglia and …
Our understanding of Alzheimer's disease (AD) pathophysiology remains incomplete. Here
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
we used quantitative mass spectrometry and coexpression network analysis to conduct the …
[HTML][HTML] Compilation of reported protein changes in the brain in Alzheimer's disease
M Askenazi, T Kavanagh, G Pires… - Nature …, 2023 - nature.com
Proteomic studies of human Alzheimer's disease brain tissue have potential to identify
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
protein changes that drive disease, and to identify new drug targets. Here, we analyse 38 …
Human and mouse single-nucleus transcriptomics reveal TREM2-dependent and TREM2-independent cellular responses in Alzheimer's disease
Glia have been implicated in Alzheimer's disease (AD) pathogenesis. Variants of the
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
microglia receptor triggering receptor expressed on myeloid cells 2 (TREM2) increase AD …
[HTML][HTML] Warburg-like metabolic transformation underlies neuronal degeneration in sporadic Alzheimer's disease
L Traxler, JR Herdy, D Stefanoni, S Eichhorner… - Cell metabolism, 2022 - cell.com
The drivers of sporadic Alzheimer's disease (AD) remain incompletely understood. Utilizing
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …
directly converted induced neurons (iNs) from AD-patient-derived fibroblasts, we identified a …
[HTML][HTML] Shared mechanisms across the major psychiatric and neurodegenerative diseases
Several common psychiatric and neurodegenerative diseases share epidemiologic risk;
however, whether they share pathophysiology is unclear and is the focus of our …
however, whether they share pathophysiology is unclear and is the focus of our …
[HTML][HTML] Proteomic landscape of Alzheimer's Disease: novel insights into pathogenesis and biomarker discovery
Mass spectrometry-based proteomics empowers deep profiling of proteome and protein
posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the …
posttranslational modifications (PTMs) in Alzheimer's disease (AD). Here we review the …