Diabetes and its complications cause a heavy disease burden globally. Identifying
exposures, risk factors and molecular processes causally associated with the development …

The treatment of polycystic ovary syndrome (PCOS) faces challenges as all known
treatments are merely symptomatic. The US Food and Drug Administration (FDA) has not …

Background The proteome is a major source of therapeutic targets. We conducted a
proteome-wide Mendelian randomization (MR) study to identify candidate protein markers …

Objectives This study aims to identify circulating proteins that are causally associated with
osteoarthritis (OA)-related traits through Mendelian randomisation (MR)-based analytical …

Background: Regarding past epidemiological studies, there has been disagreement over
whether type 1 diabetes (T1DM) is one of the risk factors for dental caries. The purpose of …

Novel druggable targets are warranted for inflammatory bowel disease (IBD) treatment. We
aimed to identify novel circulating proteins with causal associations with the risk of IBDs and …

Abstract Coronavirus disease 19 (COVID‐19) and erectile dysfunction (ED) have been
linked in some observational research, but the causality of this association in the European …

Introduction Increasing evidence suggested that plasma proteins were related to the onset
or severity of varicose veins. However, the causal association between the two had yet to be …

OBJECTIVE Proteomic profiling can identify useful biomarkers. Monozygotic (MZ) twins
discordant for a condition represent an ideal test population. We aimed to investigate and …

Learnings from these examples should facilitate other researchers to consider incorporating
research on omics technologies into their work to advance the field and our understanding …