The human gastrointestinal tract is populated with a diverse microbial community. The vast
genetic and metabolic potential of the gut microbiome underpins its ubiquity in nearly every …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

Recent single-cell RNA sequencing studies have revealed distinct microglial states in
development and disease. These include proliferative-region-associated microglia (PAMs) …

Multiple sclerosis (MS) is a prevalent neuroimmunological illness that leads to neurological
disability in young adults. Although the etiology of MS is heterogeneous, it is well …

Neuroinflammation is a key driver of neurodegenerative disease, however the tools
available to model this disease biology at the systems level are lacking. We describe a …

The greatest risk factor for neurodegeneration is the aging of the multiple cell types of
human CNS, among which microglia are important because they are the “sentinels” of …

Purpose Pathophysiological hallmarks of Alzheimer's disease (AD) include extracellular
amyloid plaques and intracellular neurofibrillary tangles. Recent studies also demonstrated …

Immune cells undergo rapid and extensive metabolic changes during inflammation. In
addition to contributing to energetic and biosynthetic demands, metabolites can also …

Clemastine, a Food and Drug Administration (FDA)-approved compound, is recognized as a
first-generation, widely available antihistamine that reduces histamine-induced symptoms …

Abstract Study Objectives Mounting evidence indicated the correlation between sleep and
cerebral small vessel disease (CSVD). However, little is known about the exact causality …