A review of classification, biosynthesis, biological activities and potential applications of flavonoids

S Chen, X Wang, Y Cheng, H Gao, X Chen - Molecules, 2023 - mdpi.com
Flavonoids represent the main class of plant secondary metabolites and occur in the tissues
and organs of various plant species. In plants, flavonoids are involved in many biological …

Immune responses in mildly versus critically ill COVID-19 patients

H Nasrollahi, AG Talepoor, Z Saleh… - Frontiers in …, 2023 - frontiersin.org
The current coronavirus pandemic (COVID-19), caused by SARS-CoV-2, has had
devastating effects on the global health and economic system. The cellular and molecular …

Multidrug resistance of cancer cells and the vital role of P-glycoprotein

C Karthika, R Sureshkumar, M Zehravi, R Akter, F Ali… - Life, 2022 - mdpi.com
P-glycoprotein (P-gp) is a major factor in the multidrug resistance phenotype in cancer cells.
P-gp is a protein that regulates the ATP-dependent efflux of a wide range of anticancer …

In COVID-19, NLRP3 inflammasome genetic variants are associated with critical disease and these effects are partly mediated by the sickness symptom complex: a …

M Maes, WLD Tedesco Junior, MAB Lozovoy… - Molecular …, 2022 - nature.com
Abstract In coronavirus disease (COVID-19), the nucleotide-binding domain, leucine-rich
repeat and pyrin domain-containing protein 3 (NLRP3) inflammasome is activated in …

Prognostic tools and candidate drugs based on plasma proteomics of patients with severe COVID-19 complications

MAY Al-Nesf, HB Abdesselem, I Bensmail… - Nature …, 2022 - nature.com
COVID-19 complications still present a huge burden on healthcare systems and warrant
predictive risk models to triage patients and inform early intervention. Here, we profile 893 …

γδ T cells: origin and fate, subsets, diseases and immunotherapy

Y Hu, Q Hu, Y Li, L Lu, Z Xiang, Z Yin… - … and Targeted Therapy, 2023 - nature.com
The intricacy of diseases, shaped by intrinsic processes like immune system exhaustion and
hyperactivation, highlights the potential of immune renormalization as a promising strategy …

COVID-19 and the promise of small molecule therapeutics: Are there lessons to be learnt?

WS Ho, R Zhang, YL Tan, CLL Chai - Pharmacological Research, 2022 - Elsevier
Abstract The coronavirus disease 2019 (COVID-19) pandemic had grounded the world to a
standstill. As the disease continues to rage two years on, it is apparent that effective …

Preeclampsia and severe acute respiratory syndrome coronavirus 2 infection: A systematic review

G Tossetta, S Fantone, N Delli Muti… - Journal of …, 2022 - journals.lww.com
Objective: Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of
the coronavirus disease 2019 (COVID-19) disease that has rapidly spread worldwide …

[HTML][HTML] SARS-CoV-2 infection and multi-organ system damage: A review

AA Rabaan, S Smajlović, H Tombuloglu… - Biomolecules and …, 2023 - ncbi.nlm.nih.gov
The SARS-CoV-2 infection causes COVID-19, which has affected approximately six hundred
million people globally as of 8 2022. Organs and cells harboring angiotensin-converting …

Vitamin D endocrine system and COVID-19: treatment with calcifediol

JM Quesada-Gomez, J Lopez-Miranda… - Nutrients, 2022 - mdpi.com
The COVID-19 pandemic is the greatest challenge facing modern medicine and public
health systems. The viral evolution of SARS-CoV-2, with the emergence of new variants with …