Tutorial: a guide for the selection of fast and accurate computational tools for the prediction of intrinsic disorder in proteins
Intrinsic disorder is instrumental for a wide range of protein functions, and its analysis, using
computational predictions from primary structures, complements secondary and tertiary …
computational predictions from primary structures, complements secondary and tertiary …
Deep learning in prediction of intrinsic disorder in proteins
Intrinsic disorder prediction is an active area that has developed over 100 predictors. We
identify and investigate a recent trend towards the development of deep neural network …
identify and investigate a recent trend towards the development of deep neural network …
AlphaFold2: a role for disordered protein/region prediction?
The development of AlphaFold2 marked a paradigm-shift in the structural biology
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
community. Herein, we assess the ability of AlphaFold2 to predict disordered regions …
Rapid prediction and analysis of protein intrinsic disorder
GW Dayhoff, VN Uversky - Protein Science, 2022 - Wiley Online Library
Protein intrinsic disorder is found in all kingdoms of life and is known to underpin numerous
physiological and pathological processes. Computational methods play an important role in …
physiological and pathological processes. Computational methods play an important role in …
Liquid–liquid phase separation underpins the formation of replication factories in rotaviruses
RNA viruses induce the formation of subcellular organelles that provide microenvironments
conducive to their replication. Here we show that replication factories of rotaviruses …
conducive to their replication. Here we show that replication factories of rotaviruses …
Intrinsic protein disorder and conditional folding in AlphaFoldDB
Intrinsically disordered regions (IDRs) defying the traditional protein structure–function
paradigm have been difficult to analyze. The availability of accurate structure predictions on …
paradigm have been difficult to analyze. The availability of accurate structure predictions on …
The Toxoplasma micropore mediates endocytosis for selective nutrient salvage from host cell compartments
W Wan, H Dong, DH Lai, J Yang, K He, X Tang… - Nature …, 2023 - nature.com
Apicomplexan parasite growth and replication relies on nutrient acquisition from host cells,
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …
in which intracellular multiplication occurs, yet the mechanisms that underlie the nutrient …
Multivalency ensures persistence of a+ TIP body at specialized microtubule ends
Microtubule plus-end tracking proteins (+ TIPs) control microtubule specialization and are as
such essential for cell division and morphogenesis. Here we investigated interactions and …
such essential for cell division and morphogenesis. Here we investigated interactions and …
DisProt in 2022: improved quality and accessibility of protein intrinsic disorder annotation
Abstract The Database of Intrinsically Disordered Proteins (DisProt, URL: https://disprot. org)
is the major repository of manually curated annotations of intrinsically disordered proteins …
is the major repository of manually curated annotations of intrinsically disordered proteins …
CAID prediction portal: a comprehensive service for predicting intrinsic disorder and binding regions in proteins
A Del Conte, A Bouhraoua, M Mehdiabadi… - Nucleic Acids …, 2023 - academic.oup.com
Intrinsic disorder (ID) in proteins is well-established in structural biology, with increasing
evidence for its involvement in essential biological processes. As measuring dynamic ID …
evidence for its involvement in essential biological processes. As measuring dynamic ID …