Complement is an ancient and complex network of the immune system and, as such, it plays
vital physiological roles, but it is also involved in numerous pathological processes. The …

Introduction. Coronavirus disease 2019 (COVID-19) identified in December 2019 in Wuhan,
China, is associated with high mortality rates worldwide. Hypothesis/Gap Statement …

ABSTRACT CD19-targeted chimeric antigen receptor T (anti-CD19 CAR-T) cells have
shown good therapeutic results in the treatment of CD19+ B cell acute lymphocytic leukemia …

Drug withdrawal elicits immune responses that contribute to the development of withdrawal
symptoms and relapse. The understanding of the immunologic dynamics after drug …

Background and objective Cytokine storm (CS) is a major contributor to the fatal outcome of
severe infectious diseases, including Covid-19. Treatment with the complement (C) C5 …

Background Polyethylene glycol (PEG) and polysorbate 80 (PS80) allergy preclude from
SARS-CoV-2 vaccination. The mechanism (s) governing cross-reactivity and PEG molecular …

A small fraction of people vaccinated with mRNA–lipid nanoparticle (mRNA-LNP)-based
COVID-19 vaccines display acute or subacute inflammatory symptoms whose mechanism …

Hemodynamic disturbance, a rise in neutrophil-to-lymphocyte ratio (NLR) and release of
inflammatory cytokines into blood, is a bad prognostic indicator in severe COVID-19 and …

Besides being a key effector arm of innate immunity, a plethora of non-canonical functions of
complement has recently been emerging. Factor H (FH), the main regulator of the alternative …

The rising need for repeated booster vaccinations against SARS-CoV-2 infections raises the
question of whether chronic immunosuppressive chemotherapies influence the efficacy of …